This pharmacology lecture covers topics such as pathophysiology and classification of seizures, action potential, excitatory and inhibitory neurotransmission (role of glutamate and GABA), voltage-gated sodium and calcium channels, AMPA and NMDA receptors, mechanism of action and side effects of ...
Pharmacology of antiepileptic drugsR. Mameniškienė
第14章 抗癫痫药和抗惊厥药 Antiepileptic and anticonvulsive drugs §1 抗癫痫药 Antiepileptic drugs Epilepsy 癫痫 chronic CNS disorders 是一种突然发生的、阵发性、短暂性、反复发作的大脑功能障碍。发作时常伴有脑电的异常 我国癫痫患病率7‰,全国癫痫患者约800万之多,每年有40万新发病人。0～9岁患者占发病...
Clinical Pharmacology UnitClinical PharmacokineticsPerucca E, Bialer M. The clinical pharmacokinetics of the newer antiepileptic drugs: focus on topiramate, ... DE Perucca,M Bialer - 《Clinical Pharmacokinetics》 被引量: 317发表: 1996年 Lamotrigine: Preliminary clinical observations on pharmacokinetics an...
Handbook of Experimental Pharmacology, Vol. 74: Antiepileptic Drugs, herausgeg. von H.‐H. Frey und D. Janz, 54 Abb., XXII, 867 S., Preis DM 680,00, Springer‐Verlag, Berlin–Heidelberg–New York–Tokyo 1985No abstract is available for this article.doi:10.1002/ardp.19853181221...
In recent years, several new antiepileptic drugs have been introduced. These drugs are used as add-on therapy in patients whose epilepsy is not controlled by established treatments. Vigabatrin is used in partial or focal epilepsy and infantile spasms. Lamotrigine is particularly useful in treating ge...
Philip N. Patsalos is Professor of Clinical Pharmacology at University College London's Institute of Neurology and Director of the Therapeutic Drug Monitoring Unit based at the Chalfont Centre for Epilepsy, Chalfont St Peter. He has more than 200 publications, has served on International League Agai...
Developmental and Therapeutic Pharmacology of Antiepileptic Drugsdoi:10.1111/j.1440-1819.1993.tb02045.xHisaoDepartmentMiuraDepartmentCROSSREFPsychiatry & Clinical NeurosciencesMiura H (2000) Developmental and therapeutic pharmacology of antiepileptic drugs. Epilepsia 9: 2-6....
Antiepileptic Drugs: Pharmacology and TherapeuticsPerucca, Emilio
This article illustrates basic principles of clinical pharmacology presented in article 1 with specific examples from the treatment of seizure disorders. The discussion includes protein binding, the role of a major carbamazepine metabolite, alterations in pharmacology of AEDs in the elderly, and AED ...