side effectsidiosyncraticteratogenicitypregnancydose‐relatedelderlyAdverse effects of antiepileptic drugs (AEDs) are frequent and rarely life-threatening. This chapter reviews common predictable reversible adverse effects and idiosyncratic adverse reactions associated with AEDs. Familiarity with these adverse ...
Antiepileptic Drug-Induced Cognitive Adverse Effects Abstract Cognitive dysfunction is frequently observed in patients with epilepsy and represents an important challenge in the management of patients with this disorder. In this respect, the relative contribution of antiepileptic drugs (AEDs) is of relevance...
抗癫痫药AntiepilepticDrugs-精品 抗癫痫药 AntiepilepticDrugs 北京协和医学院基础医学院药理学系叶菜英 Definitionsinepilepsy:Epilepsycomprisesrecurrentepisodesofabnormalcerebralneuronaldischarge.Theresultingseizuresareusuallyclinicallyobviousandvaryinpatternaccordingtowhichpartsofthebrainareaffected.Epilepsycanbecausedby...
butnotforothergeneralisedseizuretypes.Peripheralneuralgia:cranialnerve,ischiadicnerveandcranialnerve.Arrhythmia:membrane-stabilizingaction.SodiumPhenytoin 【Adverseeffects】DigestivesystemGingivalhyperplasiaNervoussystemHematologicalsystem SkeletalsystemAllergicresponseOthers SodiumPhenytoin ...
Antiepileptic drugs (AEDs) are the mainstay of treatment. Chronic use, however, often leads to serial drug changes over time, exposing patients with epilepsy (PWE) to recurrent risks due to adverse effects (AEs) and drug interactions. Both unwanted acute and chronic AEs may occur that are ...
The safety profile of anti-epileptic drugs (AEDs) is an important consideration for the regulatory bodies, owners and prescribing clinicians. Information on their adverse effects still remains limited. A systematic review including a meta-analytic approach was designed to evaluate existing evidence for ...
Finally, adverse effects can be caused by cumulative effects of long‐term therapy (Type C) [1]. As anti‐epileptic drugs (AEDs) mainly exert their pharmacodynamic properties at the central nervous system (CNS) level, the most frequent AED‐induced adverse effects affect the CNS itsel...
Carbamzepine 【Adverse effects】 ? CNS: somnolence, disequilibrium ? Gastrointestinal tract: nausea, vomiting and anorexia. ? Rash,leucopenia ,thrombocytopenia, aplastic anemia and hepatic lesion. Principle of Medication ? 1~2 times/year,no drugs are needed ? Grand pit (first choice): Sodium ...
Mula M. Recent and future antiepileptic drugs and their impact on cognition: what can we expect? Expert Review of Neurotherapeutics 2012;2:667-71.Mula, M., Recent and future antiepileptic drugs and their impact on cognition: what can we expect? Expert Rev Neurother 2012; 12(6): 667-71....
All 14 drugs have the potential to induce adverse effects, mostly CNS-related. Whilst treatment recommendations can be made for some of the drugs, these cannot be considered definitive since they are based largely on data from controlled clinical studies in highly selected patients. Further ...