Protamine is an arginine rich cationic protein and is known to be a very important pharmaceutical compound which is utilized in interventional radiology procedures, vascular surgery, and cardiac surgery, and is the only clinically approved antidote for Heparin overdose. Considering its importance in ...
To prevent blood clots during procedures such as heart surgery, doctors administer the anticoagulant heparin. In some cases—particularly overdoses—physicians need an "antidote" that binds to heparin and reverses its activity. A research team led by Jayachandran N. Kizhakkedathu of the University ...
Which is used as antidote for heparin? Expert opinion: Despite of the low therapeutic index,protamineis the only registered antidote of heparins. The toxicology of protamine depends on a complex interaction of the high molecular weight, a cationic peptide with the surfaces of the vasculature and ...
The absorption of poison into the blood from the stomach and intestine is prevented by a mechanical antidote.关键词:Antidotes Overdose Poisoning Pharmacotherapy Stock Emergency department Hospital Pharmacy DOI: 10.1016/j.farma.2011.06.009 年份: 2004 ...
a positive charge at physiological pH; and n represents the number of repetitive units of the polymer, or a copolymer thereof; for use as a medicament and for treatment of a heparin overdose wherein the polymer of formula (I) has been found to have a selectivity and affinity for heparin....
In Silico Design of Polymeric Antidote for Anticoagulant Fondaparinux The use of unfractionated heparin (UFH) and heparin derivatives as anticoagulants is an essential clinical practice in modern medicine. An overdose of thes... A Cajiao,B Gopaluni,E Kwok,... - 《Journal of Medical & Biological...
In Silico Design of Polymeric Antidote for Anticoagulant Fondaparinux The use of unfractionated heparin (UFH) and heparin derivatives as anticoagulants is an essential clinical practice in modern medicine. An overdose of thes... A Cajiao,B Gopaluni,E Kwok,... - 《Journal of Medical & Biological...