Expert opinion: Despite of the low therapeutic index,protamineis the only registered antidote of heparins. The toxicology of protamine depends on a complex interaction of the high molecular weight, a cationic peptide with the surfaces of the vasculature and blood cells. ...
Protamine is an arginine rich cationic protein and is known to be a very important pharmaceutical compound which is utilized in interventional radiology procedures, vascular surgery, and cardiac surgery, and is the only clinically approved antidote for Heparin overdose. Considering its importance in ...
例2 The nurse is caring for a client on IV heparin infusion and oral warfarin. Current laboratory values indicate that the client's aPTT is 5 times the control value and the PT/INR is 2 times the control value. What action does the nurse anticipate? 1.Clarify vegetable consumption with c...
‘classical’ agents. The three categories of heparin-likeanticoagulantsincludes unfractionated heparin,low molecular weight heparins, and synthetic saccharides with actions that depend on the presence ofantithrombin III(ATIII) in the blood, which are administered parenterally. The second group of ...
2.Decrease the heparin rate 3.Decrease the warfarin dose 4.Obtain an order for vitamin K injection 翻译 护士护理一位同时接受静脉注射肝素和口服华法林治疗的患者。最新的实验室检查结果显示患者的aPTT指标达到了正常值的5倍,PT/INR达到...
The only compound currently approved to counteract heparin is a cationic protein called protamine sulfate, but it has its drawbacks. The new agent succeeds where protamine sulfate falls short because it neutralizes the activity of all forms of heparin, a mixture of highly sulfated glycosaminoglycans ...
2.Decrease the heparin rate 3.Decrease the warfarin dose 4.Obtain an order for vitamin K injection 翻译:护士护理一位同时接受静脉注射肝素和口服华法林治疗的患者。最新的实验室检查结果显示患者的aPTT指标达到了正常值的5倍,PT/INR达到了正常值的2倍。护士应采取什么样的行动?
a commonly used blood thinner, heparin, that can be repurposed as an inexpensive antidote for cobra venom. Cobras kill thousands of people a year worldwide and perhaps a hundred thousand more are seriously maimed by necrosis, the death of body tissue and cells, caused by the v...
These companies often long for some of the spark, innovat... N Thornberry - 《European Management Journal》 被引量: 204发表: 2001年 Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (I): preparation and characterization. Low molecular weight protamine...
External Trigger Free Charge Switchable Cationic Ligands in the Design of Safe and Effective Universal Heparin Antidote Thrombosis, the formation of blood clots within a blood vessel, can lead to severe complications including pulmonary embolism, cardiac arrest, and stroke. ... CC La,SA Smith,MT ...