AcetaminophenHepatotoxicityOxidative stressNAPQIGlutathioneAcetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over the counter antipyretic and analgesic medications. It is safe at therapeutic doses, but its overdose can result in severe hepatotoxicity, a leading cause of drug-...
NAC, best known for its ability to counter acetaminophen toxicity, is a sa... KR Atkuri,JJ Mantovani,LA Herzenberg,... - 《Current Opinion in Pharmacology》 被引量: 762发表: 2007年 Corporate identity and corporate communications: the antidote to merger madness This article examines the ...
-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. NAC, best known for its ability to counter acetaminophen toxicity, is a safe, well-tolerated antidote for cysteine/GSH deficiency. NAC has been used successfully to treat GSH deficiency in a wide range of infections...
It is concluded that both drugs attenuate acetaminophen-induced hepatic toxicity, and the action is likely to be mediated through replenishment of hepatic glutathione levels. The use of zinc sulphate alone or in combination with N -acetylcysteine could be another alternative for the treatment of ...
1. The combined antidote effect of N-acetylcysteine and ethanol on the toxicity of acetaminophen was investigated. 2. Fed male mice were given acetaminophen i.p. (600 mg kg-1) and after 5 min in addition ethanol i.p. (0.2 ml, 19% v/v), N-acetylcysteine i.p. (1.2 g kg-1, 0.2...
Administration of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. NAC, best known for its ability to counter acetaminophen toxicity, is a safe, well-tolerated antidote for cysteine/GSH deficiency. NAC has been used successfully to treat GSH deficiency in a wide ...
NAC, best known for its ability to counter acetaminophen toxicity, is a sa... KR Atkuri,JJ Mantovani,LA Herzenberg,... - 《Current Opinion in Pharmacology》 被引量: 762发表: 2007年 Corporate identity and corporate communications: the antidote to merger madness This article examines the ...
Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges. One of the most common causes of acute liver failure in the Western world is paracetamol (acetaminophen) overdose. Specific and sensitive detection of live... James,W,Dear,... - ...
Nigella sativa offers protection against paracetamol-induced liver damage and nephrotoxicity [22] and has effects on hepatotoxicity and oxidative stress caused by acetaminophen. The findings of these studies indicate that thymoquinone, an antioxidant that also increases the activity of other antioxidants lik...