reversible small molecule anticoagulants for the prevention of venous thrombosis and stroke that are targeted at inhibition of FXa at its active site. ATIII is not involved in its mechanism of action. In clinical trials these drugs compare favorably with warfarin with regard to efficacy and safety...
New generation oral factor Xa and IIa inhibitors offer significant advantages over heparins and warfarin with regards to route of administration, drug interactions and predictability of bioactivity. ...
These drugs offer key benefits over the 60-year-old standard of care warfarin — including easier dosing regimens — but uptake of the newcomer drugs has been hampered by t... Mullard,Asher - 《Nature Reviews Drug Discovery》 被引量: 0发表: 2015年 Antidote for anticoagulant The present ...
The nurse is caring for a client on IV heparin infusion and oral warfarin. Current laboratory values indicate that the client's aPTT is 5 times the control value and the PT/INR is 2 times the control value. What action do...
ANTIDOTESAFETYVitamin K antagonists (VKA), such as warfarin, are widely used for prevention and treatment of arterial and venous thrombosis. Although oral ... DJ Quinlan,JW Eikelboom,JI Weitz - 《Circulation》 被引量: 45发表: 2013年 Reversible Block of the Calcium Release Channel/Ryanodine Recep...
2.Decrease the heparin rate 3.Decrease the warfarin dose 4.Obtain an order for vitamin K injection 翻译 护士护理一位同时接受静脉注射肝素和口服华法林治疗的患者。最新的实验室检查结果显示患者的aPTT指标达到了正常值的5倍,PT/INR达到了正常值的2倍。护士应采取什么样的行动?
2.Decrease the heparin rate 3.Decrease the warfarin dose 4.Obtain an order for vitamin K injection 翻译:护士护理一位同时接受静脉注射肝素和口服华法林治疗的患者。最新的实验室检查结果显示患者的aPTT指标达到了正常值的5倍,PT/INR达到了正常值的2倍。护士应采取什么样的行动?
Background: Direct FXa inhibitors appear to have superior anticoagulant efficacy and safety relative to warfarin and low molecular weight heparin. However,... Crowther,Mark,Levy,... - 《Circulation》 被引量: 44发表: 2014年 The management of hypertensive crises: a clinical review. Hypertension is...
Yet, unlike warfarin and unfractionated heparin, oral factor Xa and IIa inhibitors lack reversal agents. Therefore, concern over serious and fatal bleeds caused by oral factor Xa and IIa inhibitors is heightened. We set out ...
2.Decrease the heparin rate 3.Decrease the warfarin dose 4.Obtain an order for vitamin K injection 翻译 护士护理一位同时接受静脉注射肝素和口服华法林治疗的患者。最新的实验室检查结果显示患者的aPTT指标达到了正常值的5倍,PT/INR达到了正常值的2倍。护士应采取什么样的行动?