Current antidotal regimens for OP poisoning consist of a combination of pretreatment with a spontaneously reactivating reversible AChE inhibitor such as pyridostigmine bromide, and post-exposure therapy with anticholinergic drugs such as atropine sulfate and oximes such as 2-PAM chloride (Gray, 1984)....
may occur with alcohol or other xenobiotics, while understanding of the latter led to the development of antidotes for the treatment of acute poisoning. Ac... SD Cohen,EA Khairallah - 《Drug Metabolism Reviews》 被引量: 316发表: 1997年 Review of Oximes in the Antidotal Treatment of Poisoning...
Magnesium sulfate is a salt of magnesium, a naturally occurring mineral that is important for the normal functioning of many systems in the body, including nerve function, electrical conduction in the heart, protein synthesis, bone formation andblood pressureregulation. Magnesium sulfate (antidote) is...
Atropine/pralidoxime is approved by the FDA for self or buddy-administration by military personnel who have been exposed to nerve agents such as sarin, soman, tabun or VX, and administration by trained emergency medical services personnel to treat organophosphate poisoning from insecticides, in adult...
Human butyrylcholinesterase (BChE) is a well-characterized bioscavenger with significant potential as a prophylactic or post-exposure treatment for organophosphate poisoning. Despite substantial efforts, BChE has proven technically challenging to produce in recombinant systems. Recombinant BChE tends to be...
To describe the demographic characteristics, clinical course, and outcome of children with acute organophosphate (OP) poisoning admitted to a regional medi... F Levy-Khademi,AN Tenenbaum,ID Wexler,... - 《Pediatric Emergency Care》 被引量: 29发表: 2007年 ...
It is aimed at promoting a dialogue that leads to a well-constructed, coherent proposal that serves as the basis for an effective new model of strategic management for HEIs in specific contexts.Dereje KebebeMebruka GobenaRamya Krishna Seelam...
Chemical Aspects of Pharmacological Prophylaxis Against Nerve Agent Poisoning Detoxification is realised by administration of the enzymes splitting the OP or exploitating specific enzymes (cholinesterases). OP/nerve agent is bound to ... Jiri Bajgar, Josef Fusek, Jiri Kassa, Kamil Kuca, Daniel Jun...
Taking into account the above, nanometric MIL-125-NH2 seems to be an appropriate tool for optimizing the treatment of nerve agent poisoning by the potential VOC degradation as well as vectorization and controlled release of antidotes. Therefore, we present here the synthesis of high yields of ...