The inclusion of amitriptyline in the first WHO list of Essential Drugs (1977) cemented its status. All the 'new' psychopharmaceuticals came to Nepal, but they never displaced the 'old' amitriptyline. No other drug could beat amitriptyline's affordability, availability, and efficacy for the ...
(36.2)1.0024-28112 (20.2)399 (19.4)1.01 (0.77-1.32)>2869 (12.4)318 (15.4)0.85 (0.62-1.17)Unknown167 (30.1)598 (29.0)1.03 (0.81-1.32)*Controls were matched to cases by age, sex, index date, and duration of recorded history in the UK General Practice Research Database before the index...
Chronic pain affects between one-third and one-half of the UK population. The treatment of chronic pain is often suboptimal, with commonly used medicines having limited or unknown benefits, and sometimes harmful side effects. Antidepressants are prescribed to help manage chronic pain, e...
In defiance of dualist metaphysics, opioids tend to be good at banishing both. Contemporary medical orthodoxy classifies drug-induced bliss as an "adverse side-effect" of opioid analgesics - even in the terminally ill. Yet we could all do with having our native endorphin systems enriched. ...
intimatelink between "physical" and "emotional" pain. In defiance of dualist metaphysics, opioids tend to be good at banishing both. Contemporary medical orthodoxy classifies drug-induced bliss as an "adverse side-effect" of opioidanalgesics- even in the terminally ill. Yet we could all do ...
A list of potentially eligible studies was constructed by consensus, after which full-text examinations were conducted. A third reviewer (CK Sun) was consulted if any inconsistencies arose. Eligibility criteria The inclusion criteria were: (1) peer-reviewed articles investigating the efficacy of ...
During the last 2 weeks of the uCMS, animals were injected intraperitoneally daily with one of the four ADs: fluoxetine (10 mg/kg in ultra-pure water; Kemprotec, Middlesborough, UK); imipramine (10 mg/kg in 0.9% saline solution; Sigma-Aldrich, St Louis, MO, USA); tianeptine (...
It should be remembered that this antidepressant, before the pandemic, was the second most prescribed in China, quite consumed in Europe and in the UK. In the first confinement, in 2020, it was the most used antidepressant in the USA (40 %) (Montgomery et al., 2021). However, in ...
London, UK: International Policy Network Google Scholar Committee THoCH: The influence of the pharmaceutical industry. 2006, London, The House of Commons, 18-20. vol. vol.2 Google Scholar Whitehead BJ, Kempner Stuart, Kempner R: Managing generic competition and patent strategies in the ...
Why everything feels 'off' right now. Justin shares cryptic post about imposter syndrome Are you battling popcorn brain? Here's how to deal "I tried a sound bath for my anxiety" Crackdown on how easy it is to buy weight loss jab ...