mechanism of actionThrombotic disorders are a major cause of morbidity and mortality in humans. Examples of thrombotic disorders include pulmonary embolism, deep vein thrombosis, disseminated intravascular coagulation, acute myocardial infarction, unstable angina, and cerebrovascular thrombosis. Anticoagulants ...
The non-vitamin K antagonist oral anticoagulants (NOACs) include direct inhibitors of factor Xa or thrombin. In this Review, Levy and colleagues describe the mechanism of action of the NOAC-reversal strategies, provide guidance on potential indications for reversal, and offer a management approach ...
). See also “Periprocedural management of oral anticoagulant therapy” and “Anticoagulation reversal.”Overview Overview of commonly used oral anticoagulantsOverview of commonly used oral anticoagulants Mechanism of actionAdvantagesDisadvantages Vitamin K antagonists (coumarins)...
Oral Anticoagulants: Mechanism of Action, Clinical Effectiveness, and Optimal Therapeutic Range Four new oral anticoagulants compare favourably with warfarin for stroke prevention in patients with atrial fibrillation; however, the balance between effi... Jack,Hirsh,James,... - 《Chest》 被引量: 2704...
Ciraparantag, an anticoagulant reversal drug: mechanism of action, pharmacokinetics, and reversal of anticoagulants - ScienceDirectCiraparantag, an anticoagulant reversal agent, is a small molecule specifically designed to bind noncovalently by... J Ansell,BE Laulicht,SH Bakhru,... 被引量: 0发表...
Their increased use means that oral care clinicians should have a sound understanding of the mechanism of action, pharmacology, reversal strategies and management of bleeding in patients taking these drugs. Surprisingly, there is little published in the current literature specific to professionals ...
These drugs have been around for over half a century and we continue to evolve our understanding of their mechanism of action and the best way to use them. There is little doubt that both heparin and warfarin have served us well but it is also fair to acknowledge that their use has come...
The Mechanism of Action of Oral Anticoagulants and Its Consequences for the Practice of Oral Anticoagulation Hemker HC, Frank HL (1985) The mechanism of action of oral anticoagulants and its consequences for the practice of oral anticoagulation. Haemostasis 15: ... HC Hemker,HLL Frank - 《Pathoph...
Based on their mechanism of anticoagulant action, they can be broadly classified as: * Thrombin inhibitors * FXa inhibitors * Extrinsic tenase complex inhibitors * Intrinsic tenase complex inhibitors Thrombin inhibitors The most well-known example of thrombin inhibitor, hirudin, was isolated more than ...
Presents case studies on the mechanism of action of circulating anticoagulants in patients with systemic lupus erythematosus. Medical history of the patien... O Castro,LR Farber,LP Clyne - 《Annals of Internal Medicine》 被引量: 58发表: 1972年 Circulating anticoagulants to factor VIII Circulating ...