Mechanism of action of anticoagulants : correlation between the inhibition of prothrombin synthesis and the regeneration of vitamin K 1 from vitamin K 1 epoxide . J Pharm Exp Ther ; 201 : 541.Ren P, Stark PJ, Johnson RL, Bell RG (1977) Mechanism of action of anticoagulans: correlation ...
The non-vitamin K antagonist oral anticoagulants (NOACs) include direct inhibitors of factor Xa or thrombin. In this Review, Levy and colleagues describe the mechanism of action of the NOAC-reversal strategies, provide guidance on potential indications for reversal, and offer a management approach ...
See also “Periprocedural management of oral anticoagulant therapy” and “Anticoagulation reversal.” Register or log in , in order to read the full article.Overview Overview of commonly used oral anticoagulantsOverview of commonly used oral anticoagulants Mechanism of actionAdvantagesDisadvantages ...
clinical cardiologists, aims to: 1) review the mechanism of action, pharmacologic properties, and side effects of the new anticoagulants; and 2) describe and comment on the results of recently completed clinical trials in 2 specific cardiac conditions, atrial fibrillation and acute coronary syndromes...
Hirsh J, Dalen J, Anderson DR et al (2001) Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest 119:8S–21S Article CAS Google Scholar Ansell J, Hirsh J, Hylek E et al (2008) Pharmacology and management of the vitamin K antagonists: Americ...
With increasing use of DOACs, adequate knowledge regarding the perioperative management of patients on DOACs has become indispensable. Areas covered: This review covers the indications, mechanism of action, and pharmacokinetics of DOACs and their management in different perioperative settings based on ...
Oral Anticoagulants: Mechanism of Action, Clinical Effectiveness, and Optimal Therapeutic Range Author information: (1)Department of Medicine, McMaster University, Hamilton, Ontario, Canada. J Hirsh,JE Dalen,D Deykin,... - 《Chest》 被引量: 3114发表: 1995年 Oral Anticoagulants: Mechanism of Actio...
Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range. Chest. 2001;119:8–21. 2. Gong IY, Kim RB. Importance of pharmacokinetic profile and variability as determinants of dose and response to dabigatran, rivaroxaban, and apixaban. Can J Cardiol. 2013;29:...
On the downside, VKAs have an indirect anticoagulant mechanism of action, impairing the synthesis of several vitamin K-dependent coagulation factors (Fig.1), which results in a slow onset and offset of the anticoagulant effect. On initiation, VKAs are inherently prothrombotic (a fact often overlook...
How can disseminated intravascular coagulation (DIC) cause ischemia, thrombosis, and bleeding? First define what DIC is, its causes and mechanism of action. The enzyme responsible for breaking up a blood clot is A. fibrinogen B. ATPase C. coagulase D. plasminogen E. plasmin ...