aturboSmooth 正在翻译,请等待... [translate] a大厅里挤满了等待面试的学生。翻译 in the hall was packed with students waiting for the interview. Translation; [translate] athe number of peptide-, protein-, and antibody-based drugs 肽,蛋白质和基于抗体的药物的数量 [translate] ...
Drugs AgingDrugs & AgingLiu J, Yang B, Ke J, Li W, Suen WC (2016) Antibody-Based Drugs and Approaches Against Amyloid-β Species for Alzheimer's Disease Immunotherapy. Drugs Aging 33: 685-697.Liu J, Yang B, Ke J, Li W and Suen WC (2016) Antibody-based drugs and approaches ...
Many therapeutic drugs in use today are engineered monoclonal antibodies targeting a diverse range of diseases, including autoimmune disorders such as arthritis, psoriasis, and inflammatory bowel disease, and cancers such as lymphomas, breast cancer, and many others. Depending on the target, the ...
Microtubules represent a validated oncologic target in a range of tumor types, with a number of anti-microtubule targeting cytotoxic drugs approved for cancer use. The systemic use of potent microtubule-binding agents is limited by their effects in normal cells, which leads to toxicity including ...
The use of monomethyl auristatin E (MMAE) as a payload is prevalent in the development of ADC drugs, with five out of the fifteen approved ADCs utilizing this agent (Table 1).2 Upon recognition and binding of target antigens expressed on the surface of cancer cell, the ADC is internalized...
To counter this, and to target α-syn inside cells as well, antibody-based drugs that prevent the aggregation and spread of toxic α-syn may alter the course of disease [25]. However, current clinical α-syn immunotherapies based on whole IgG antibodies (150 kDa) have difficulty crossing ...
In this last decade of the 20th century the efficacy of antimicrobial chemotherapy is diminishing because of the rapidly escalating number of immunocompromised individuals, the emergence of new pathogens, the reemergence of old pathogens, and widespread development of resistance to antimicrobial drugs. ...
Combined, these results suggest that the cathepsin cleavage sites for conjugated drugs are exposed enough for the enzyme to access and that the drug release rate is rather independent of drug location or monoclonal antibody carrier. Therefore, the distribution of drug conjugation at different sites ...
Furthermore, the toxicity of chemotherapeutic drugs affects tumor cells and the normal cells in parallel, which results in the damage of the immune system and causes a variety of physical disorders in patients such as nausea, vomiting, hair loss, cognitive disorder, and blood cell reduction. ...
Section Editor:Gary Woodnutt 鈥 Diversa Corp., San Diego, CA, USAThe emergence of new pathogenic microorganisms combined with the inexorable increase in resistance and the relative lack of new small molecule drugs for infectious disease ... JF Kokai-Kun,JJ Mond - 《Drug Discovery Today Therapeut...