: an antibody (as heterophile antibody) active against a Forssman antigen Word History Etymology after John Forssman †1947 Swedish pathologist The Ultimate Dictionary Awaits Expand your vocabulary and dive deeper into language with Merriam-Webster Unabridged. Expanded definitions Detailed ...
antigen [an´tĭ-jen] any substance capable, under appropriate conditions, of inducing a specific immune response and reacting with the products of that response; that is, with specific antibody or specifically sensitized T lymphocytes, or both. Antigens may be soluble substances, such as tox...
(Table 1) and elsewhere. Serotonin was one of the earliestneurotransmittersexamined in this way and, along withsubstance P, was one of the first antigens to benefit from themonoclonal antibodyrevolution (Panguluri et al., 2009). The “YC5/45” IgG2cantiserotoninantibody and the NCl/34 (...
In serum, circulating TSH-receptor subunits are found that have been shown to be a possible antigen in the autoimmune disease process. The thyrotropin receptor on thyroid follicular cells is the target of autoantibodies, the thyrotropin receptor antibodies (TRAb). These fall into two general classes...
an antigen may effect production of antibodies directed at numerous epitopes. Polyclonal antibodies are mixtures of serum immunoglobulins and collectively are likely to bind to multiple epitopes on the antigen. Monoclonal antibodies ...
Here improvements in quality need to be chiefly directed towards achieving an exact definition of the antigens/antibodies contained in such standards. When defined recombinant antigens or monoclo- nal antibodies are used, however, the utility of the standard Quantificationfor thefollowing questions: ...
Hodgkinson VS, Egger S, Betsou F, Waterboer T, Pawlita M, Michel A, et al. Preanalytical stability of antibodies to pathogenic antigens. Cancer Epidemiol Prevent Biomarkers. 2017;26(8):1337–44. Article CAS Google Scholar Hendriks J, Stals C, Versteilen A, Mommaas B, Verhoeven M, ...
Antigen information: as published by supplier or provided on request (*: information is considered ambivalent for four peptides, consequently shown aa sequences may not reflect exact antigen peptides, but are based on “informed assumption” that the V7 specific unique 16 aa are part of all ...
3.1 Detection of antigen Antigen can stimulate the immune response to produce antibodies, mainly including the proteins on the virus surface (such as the capsid protein p24 of HIV (Du et al. 2019)). Considering the high infectivity and pathogenicity of viruses, the vaccines which have been att...
Antibody–drug conjugates (ADCs) are rapidly evolving therapies that are uniquely able to deliver potent chemotherapy specifically to cancer cells while largely sparing normal cells. ADCs have 3 components: (1) antibody targeted to a tumor-involved antigen, (2) cytotoxic payload, and (3) linker ...