disease burden of RSV in high-risk infant populations.Motavizumab (MEDI-524, NUMAX, NISTmAb) has higher affinity and a longer half-life, was effective in reducing RSV hospitalization in high-risk full-term infants in the US, but was not licensed due to safety concerns (allergic reactions) ...
Streptokinase used as a thrombolytic agent may produce immunologic drug reactions. We report a second case of IgE-mediated anaphylaxis and a late reaction to streptokinase. This late reaction was consistent with an IgG-mediated antigen-antibody disease with transient renal involvement, fever, and ...
Six subjects had adverse reactions that were probably or possibly due to allergy to components of the antibody preparation. Of these 4 (5%; 95% confidence interval (Cl) 1.8% to 12%) occurred in the 82 subjects with histories of allergy or asthma and 3 (9%; 95% Cl 1.8% to 23%) of...
The presence of IgG anti-IgA in the serum of primary immunodeficiency (PID) patients has long been considered responsible for hypersensitivity (HS) to immunoglobulin preparations (IgPs), but this link is increasingly being questioned. The aim of this work was to describe the prevalence of IgG ...
Chronic Obstructive Pulmonary Disease (COPD) includes patient populations with varying degrees of chronic bronchitis, small airway disease and emphysema and is characterised by progressive irreversible lung function decline that responds poorly to current asthma based therapy [90]. The incidence of COPD ha...
Although there was a trend towards an overall reduction in opsonophagocytic function in individuals with immediate allergic reactions compared to non-allergic controls, allergic patients produced functional antibodies exhibiting a high ratio of opsonophagocytic function to IgG1 titer....
Interference between two different , strain KO-85. Skin reactions of the Arthus type elicited by the CP fraction inhibited passive cutaneous anaphylaxis (PCA) induced by bovine serum albumin (BSA) and rabbit anti-BSA serum. PCA reactions of the CP-sensitized animals were also inhibited upon ...
Allergic reactions to streptokinase consistent with ana- phylactic or antigen-antibody complex mediated damage. J ALL~aG¥CLINIMMUNOL1985;76:453-7.McGrath KG, Zeffren B, Alexander J, et al. Allergic reactions to streptokinase consistent with anaphylactic or antigen-antibody complex-mediated ...
Disclosed are bi-specific complexes aimed at inhibiting mast cells, eosinophils and/or basophils, and thus, at inhibiting allergy-type reactions. In particular, said complexes are best exemplified by bi-specific antibodies, which bind to two targets present in the same cell. One target is the ...
Multispecific binding of ligands to a mouse monoclonal anti-DNP IgE antibody. Mol Immunol 1991, 28:641-654.Varga JM, Kalchschmid G, Klein GF, Fritsch P. Mechanism of allergic cross-reactions: Multi- specific binding of ligands to a mouse monoclonal anti-DNP IgE antibody. Mol Immunol 1991;...