系统标签: antibody structure function antibodies monoclonal kabat 58 4 ANTIBODYSTRUCTUREANDFUNCTION CHAPTEROUTLINE OBJECTIVES 1.Thestructureofanantibodyisrelatedtoitsfunction. a.StudiesbyTiseliusandKabatandlaterbyEdelman, Porter,andNisonoffdeterminedthebasicstructural componentsofantibodies. 1)Initially,antibodieswer...
1Introduction:AntibodyStructureandFunctionArvindRajpal,PavelStrop,YikAndyYeung,JavierChaparro-Riggers,andJaumePons1.1IntroductiontoAntibodiesAntibodies,acentralpartofhumoralimmunity,haveincreasinglybecomeadominantclassofbiotherapeuticsinclinicaldevelopmentandareapprovedforuseinpatients.Aswithanysuccessfulendeavor,thehistoryofmo...
Introduction: Antibody structure and function. In: Chamow SM, Ryll T, Lowman HB, Farson D, editors. Therapeutic Fc-fusion proteins. Weinheim: Wiley-Blackwell; 2014. p. 1–44.Rajpal, A.; Strop, P.; Yeung, Y.; Chaparro, J.; Pons, J. Introduction: Antibody structure and function. In...
4 ANTIBODY STRUCTURE AND FUNCTION CHAPTER OUTLINE 1. The structure of an antibody is related to its function. a. Studies by Tiselius and Kabat and later by Edelman, Porter, and Nisonoff determined the basic structural components of antibodies. 1) Initially, antibodies were identified only by ...
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Structure and function of immunoglobulins. J. Allergy Clin. Immunol. 125, S41–52 (2010). Article PubMed PubMed Central Google Scholar El-Madhun, A. S., Cox, R. J. & Haaheim, L. R. The effect of age and natural priming on the IgG and IgA subclass responses after parenteral ...
and is believed to be the major protective antigenic region in SARS-CoV (Chen et al., 2005). The prefusion structure of the S protein of SARS-CoV-2 was recently determined by cryogenic electron microscopy (cryo-EM) (Wrapp et al., 2020) and revealed an overall structural similarity to ...
Lecca, I. Laurenzi and F. Jordan 22 Protein folding in silico: Protein folding versus protein structure prediction I. Roterman 23 Computer-aided vaccine design T.J. Chuan and S. Ranganathan 24 An introduction to biotechnology W.T. Godbey 25 RNA interference: Therapeutic developments T. Novo...
Structural and functional basis of SARS-CoV-2 entry by using human ACE2. Cell 181, 894–904 (2020). Article CAS PubMed PubMed Central Google Scholar Walls, A.C. et al. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell 181, 281–292 (2020). Article ...
Antibody structure and function: the basis for engineering therapeutics 10.3390/antib8040055 View in Scopus Google Scholar [2] N. Jenkins, L. Murphy, R. Tyther Post-translational modifications of recombinant proteins: significance for biopharmaceuticals ...