In vivo pharmacokinetics (PK) studies using mice and monkeys are the main approaches for evaluating and predicting the PK of antibodies, and there is a strong demand for methods that do not require animal experiments. In this work, we focused on quantitatively predicting the nonlinear PK of an ...
Schou O, Foley KP, Haugen H, McMillen S, Waggie K, Schreckhise RW, Shoemaker K, Vu T, Moore M, Grossman A, Clegg CH. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity. 2001;15:289–302. ...
Validation of ADCs in vivo Finally, we evaluated the ADCs in vivo using mouse models. We first assessed PK profiles of VCit, SVCit, and EVCit ADCs3a–cusing BALB/c mice. Mice were treated with intravenous injection of each ADC or the parental N297A anti-HER2 mAb (3 mg kg–1)...
A mouse monoclonal antibody is a type of antibody produced by a single clone of immune cells derived from mice. The specificity and affinity of mouse monoclonal antibodies make them a valuable resource for a wide range of applications, such as research and development (R&D), diagnostics, and th...
Beta Actin Antibody Western Blot validation (1:10000 dilution) in 293T (Cat no:66009-1-Ig) FH Priya (Verified Customer) (06-21-2023) Used this antibody for Caco2 cells andmice tissue Applications:Western Blot Primary Antibody Dilution:1 to 1000 ...
In order to find out whether the amyloid plaques could be removed, the researchers focused on antibodies that recognize and bind to APOE. The researchers at Washington University School of Medicine tested several antibodies that recognize human APOE in mice genetically predisposed to develop amyloid pl...
GAPDH Antibody Western Blot, validation (1:1000 dilution) in brain lysate (Cat no:60004-1-Ig) FH JIMMY (Verified Customer) (03-26-2019) This antibody offers a good detection of GAPDH on mouse cells such as macrophages and microglia through western blots. ...
in cells. Protein kinase C alpha by PRKCA is one of the PKC family members. Protein kinase C alphahas been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest...
Although IL-6 is involved in various inflammatory and immune diseases, the roles of IL-6 in autoimmune-related pain have not been clarified. Therefore, we examined the effect of anti-IL-6 receptor antibody (MR16-1) on the pain sensitivity of experimental autoimmune encephalomyelitis (EAE) mice...
Pharmacokinetics and pharmacodynamics of DSTA4637A: a novel THIOMAB antibody antibiotic conjugate against Staphylococcus aureus in mice. mAbs 8, 1612–1619 (2016). Article CAS PubMed PubMed Central Google Scholar Hamilton, G. S. Antibody–drug conjugates for cancer therapy: the technological and ...