Tony Mazzulli, in Principles and Practice of Pediatric Infectious Diseases (Fourth Edition), 2012 Epstein–Barr Virus In patients with suspected EBV mononucleosis (IM), heterophile antibody remains the serologic test of choice.101 These IgM antibodies can be detected easily and rapidly using a simpl...
DNA-based assays can be used to antigen-type donor blood both for transfusion and for antibody identification reagent panels. This is particularly useful when antibodies are not available or are weakly reactive. A good example is the Dombrock blood group polymorphism, where DNA-based assays112–11...
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In routine practice, these types of antibodies are often categorized as having an undetermined specificity due to their rarity and low prevalence in the population. We describe two cases of successful ID of rare and low-incidence red cell alloantibodies, Anti-Colton-b (Co(b)) and Anti-Kpa. ...
Panels above show the gating strategy for unstimulated myeloid APCs co-cultured with Toledo CD20+ tumor cells. A dose dependent response analogous to that measured with MFI (as reported in Fig. 1 and elsewhere) is observed when computed as percent positive of total myeloid APCs. Data shown (...
HIV-1 infection remains a public health problem with no cure. Anti-retroviral therapy (ART) is effective but requires lifelong drug administration owing to a stable reservoir of latent proviruses integrated into the genome of CD4+ T cells1. Immunotherapy
The BG505 SOSIP.664 recombinant Env glycoprotein trimer was produced in CHO cells under current good manufacturing practice conditions as described previously46and was obtained from the International AIDS Vaccine Initiative. The preparation of PLGA nanoparticles encapsulating 3M-052 and the details of rec...
The mean time between the first and second Cunningham Panels in Group 1 was 68.1 weeks, versus 66.2 weeks in Group 2 (p = 0.87). The median time between tests for Group 1 was 48 weeks, versus 62 weeks for Group 2. An interesting observation in examining symptom frequency is that ...
Daudi cells were seeded at day 0 in 1 ml of culture medium containing (as indicated on top of the panels) 5 μg/ml of hLL1, or hLL2 (an anti-CD22, internalizing Ab), or no any Ab (Ni1), with 50 μg/ml of -hFc Ab, or without (Ni1), indicated at right side of panels....
(a) a first VH CDR of SEQ ID NO: 1 (GFMFSSYW); (b) a second VH CDR of SEQ ID NO: 2 (INKDVTTT); (c) a third VH CDR of SEQ ID NO: 3 (VRNHGSRYAYFDV); ...