Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. It combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of can...
Antibody drug conjugate: the “biological missile” for targeted cancer therapy Article Open access 22 March 2022 Homogeneous multi-payload antibody–drug conjugates Article 17 May 2024 References Joubert, N., Beck, A., Dumontet, C. & Denevault-Sabourin, C. Antibody–drug conjugates: the la...
抗体偶联药物(Antibody-Drug Conjugate,ADC)是由靶向特异性抗原的抗体或抗体片段与有效载荷(payload)通过连接子(linker)偶联而成的一类创新型抗体药物。与传统抗体药物相比,ADC产品兼具传统小分子药物强效作用及抗体药物的靶向性,以降低全身毒性并更有选择性地将有效载荷递送至肿瘤细胞、肿瘤微环境或其他靶细胞中,近年来...
Antibody drug conjugate: the “biological missile” for targeted cancer therapy Signal Transduction and Targeted Therapy(IF40.8)Pub Date : 2022-03-22, DOI:10.1038/s41392-022-00947-7 Zhiwen Fu1, 2, Shijun Li1, 2, Sifei Han3, 4, Chen Shi1, 2, Yu Zhang1, 2 ...
FEBS J. 2020 May;287(10):1936-1969. [3] Antibody drug conjugate: the “biological missile” for targeted cancer therapy [4] Reducing the Complexity of Fc Glycan Enables the Construction of Antibody Conjugates with Unexpected High Efficiency and Payload Capacity via Glycoengineering...
2. Z. W. Fu, S. J. Li, S. F. Han, C. Shi and Y. Zhang,“Antibody drug conjugate: the "biological missile" for targeted cancer therapy,” J. Signal Transduct Target Ther. 7(1), 93 (2022). https://doi.org/10.1038/s41392-022-00947-7 ...
抗体药物偶联物(Antibody-drug conjugate, ADC)是通过化学键将具有生物活性的细胞毒药物连接到单克隆抗体(mAb)上,单克隆抗体(mAb)作为载体将细胞毒药物靶向运输到目标细胞中发挥作用的一类药物。 2. 特点 抗体药物偶联物(Antibody-drug conjugate, ADC)既具有细胞毒药物杀伤力强大的特点,又结合了重组单克隆抗体(mAb)...
抗体药物偶联物(Antibody-drug conjugate, ADC)是通过化学键将具有生物活性的细胞毒药物连接到单克隆抗体(mAb)上,单克隆抗体(mAb)作为载体将细胞毒药物靶向运输到目标细胞中发挥作用的一类药物。 2. 特点 抗体药物偶联物(Antibody-drug conjugate, ADC)既具有细胞毒药物杀伤力强大的特点,又结合了重组单克隆抗体(mAb)...
ADC 抗体药物偶联物Antibody Drug Conjugate通过化学链接将具有生物活性的小分子药物连接到单抗上产生的药物,单抗作为载体将小分子药物靶向运输到目标细胞中 PROTACS蛋白水解靶向嵌合體Proteolysis-Targeting Chimeras 蛋白水解靶向嵌合体(Proteolysis-Targeting ChimerasPROTACS)技术作为一种新的治手段,在抗肿瘤物领域中得到了广泛...
Antibody drug conjugate: the “biological missile” for targeted cancer therapy. Signal Transduct. Target. Ther. 7, 93 (2022). Article CAS PubMed PubMed Central Google Scholar Majzner, R. G. et al. GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. Nature 603, 934–...