Antibody–drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the potency of highly cytotoxic agents, potentially reducing the severity of side effects by preferentially targeting their payload to the tumour site. ADCs are being
Antibody-drug conjugate (ADC) clinical pipeline: a review. Methods Mol Biol. 2013;1045:1-27.Sassoon I, Blanc V. Antibody-drug conjugate (ADC) clinical pipeline: a review//Ducry L, Ed. Antibody-Drug Conjugates. Methods in Molecular Biology Volume 1045. Humana: Humana Press, 2013: 1-27....
Antibody–drug conjugate (ADC) is typically composed of a monoclonal antibody (mAbs) covalently attached to a cytotoxic drug via a chemical linker. It combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of can...
Antibody鈥揇rug Conjugate (ADC) Clinical Pipeline: A Review Antibody-drug conjugate (ADC) clinical pipeline: A review. Methods Mol Biol 2013;1045:1-27.Sassoon, I.; Blanc, V. Antibody-drug conjugate (ADC) ... I Sassoon 被引量: 0发表: 2013年 Enthusiasm for antibody-drug conjugates. (15...
A comprehensive review of key factors affecting the efficacy of antibody drug conjugate AnupamaSamantasinghar, ...Kyung HyunChoi, inBiomedicine & Pharmacotherapy, 2023 1Introduction Antibody Drug Conjugate(ADC) is an emerging class of potent biological drugs that combine a highly potent cytotoxic ...
抗体-药物复合体 Antibody-Drug Conjugate 抗体-药物复合体(Antibody-Drug Conugate, ADC)是由单克隆抗体(mAb)与小分子药物(payload)通过恰当的连接体相连,经过生物体偶联(bioconjugation)结合而成的一种医药品。 作为一种新型医药品,兼具了小分子药物与抗体医药的优点受到世界各研究组的关注。
抗体药物偶联物(Antibody-drug conjugate, ADC)是通过化学键将具有生物活性的细胞毒药物连接到单克隆抗体(mAb)上,单克隆抗体(mAb)作为载体将细胞毒药物靶向运输到目标细胞中发挥作用的一类药物。 2. 特点 抗体药物偶联物(Antibody-drug conjugate, ADC)既具有细胞毒药物杀伤力强大的特点,又结合了重组单克隆抗体(mAb)...
the antibody–siRNA conjugates (ARC) have emerged as a potential vehicle for targeted siRNA drug delivery, with the ability to overcome the current obstacles in siRNA delivery. In this review, we summarized the efforts in the development of antibody–siRNA conjugates and hope to provide a basic ...
抗体药物偶联物(Antibody-drug conjugate, ADC)是通过化学键将具有生物活性的细胞毒药物连接到单克隆抗体(mAb)上,单克隆抗体(mAb)作为载体将细胞毒药物靶向运输到目标细胞中发挥作用的一类药物。 2. 特点 抗体药物偶联物(Antibody-drug conjugate, ADC)既具有细胞毒药物杀伤力强大的特点,又结合了重组单克隆抗体(mAb)...
emerging data of which appears promising. As we deepen our understanding of what makes a successful ADC, an increasing number of ADCs will likely become viable treatment options as single agents or in combination with chemotherapy. This review will present the philosophy underlying ADCs, their main...