Penichet M L,Morrison S L.Antibody-cytokine fusion proteins for the therapy of cancer. Journal of Immunological Methods . 2001Antibody-cytokine fusion proteins for the therapy of cancer. Penichet M L,Morrison S L. Journal of Immunological Methods . 2001...
In addition, in animals bearing tumors, antibody–cytokine fusion proteins are able to target the tumor and to elicit a significant anti-tumor response that in some cases results in a complete elimination of the tumor. These results suggest that antibody–cytokine fusion proteins have potential for...
In addition, in animals bearing tumors, antibody–cytokine fusion proteins are able to target the tumor and to elicit a significant anti-tumor response that in some cases results in a complete elimination of the tumor. These results suggest that antibody–cytokine fusion proteins have potential for...
Antibody–cytokine fusion proteins: a novel class of biopharmaceuticals for the therapy of cancer and of chronic inflammation. N. Biotechnol. 52, 42–53 (2019). CAS PubMed PubMed Central Google Scholar Ding, H. et al. Polymalic acid nanobioconjugate for simultaneous immunostimulation and ...
M. Antibody–cytokine fusion proteins for treatment of cancer: engineering cytokines for improved efficacy and safety. Semin. Oncol. 41, 623–636 (2014). Article CAS PubMed PubMed Central Google Scholar Overwijk, W. W., Tagliaferri, M. A. & Zalevsky, J. Engineering IL-2 to give new...
By fusing a cytokine (e.g., IL-2) to an antibody (e.g. IgG3), a molecule has been created with the functional characteristics of both proteins. The pharmacokinetic properties of such a fusion protein may be greatly improved over those of cytokine alone (e.g., IL-2) and previously de...
Different antibody or antibody fragment-cytokine fusion proteins.aCytokine fused to the N-terminus of the Fc domain;bCytokine fused to the C-terminus of the Fc domain;cCytokine fused to the C-terminus of the Fab;dCytokine fused to the C-terminus of the scFv;eScFv-cytokine-scFv fusion prote...
Preliminary testing has shown in vitro and in vivo that antitumor activity can be obtained with fusion proteins linking -reactive monoclonal antibodies to cytokines, such as or interleukin 2 (). Preclinical and clinical testing of these reagents requires their in vitro and in vivo quantitation and ...
By increase of antibody-cytokine fusion proteins mediated immune responses by a combined treatment with agents for increasing the immunzytokinaufnahme S Gillies,S Holden,Y Lan 被引量: 0发表: 2001年 Eradication of established hepatic human neuroblastoma metastases in mice with severe combined ...
302–Targeted cytokine delivery with recombinant antibody fusion proteins for therapeutic interventionScitation is the online home of leading journals and conference proceedings from AIP Publishing and AIP Member Societiesdoi:10.1063/1.1655849Holger N. Lode...