Thus, it is apparent that CD117-ADC pre-treatment fosters establishment of a state of hematopoietic chimerism post BMT even across complete MHC-mismatch which promotes a state of clinical tolerance as defined by (1) long-term survival of a well-functioning allograft without immunosuppression in an...
Lyon, R. Drawing lessons from the clinical development of antibody–drug conjugates. Drug Discov. Today Technol. 30, 105–109 (2018). PubMed Google Scholar Herrera, A. F. et al. Anti-CD79B antibody-drug conjugate DCDS0780A in patients with B-cell non-Hodgkin lymphoma: phase 1 dose-...
Moreover, special clinical conditions, such as pregnancy, outlined in this manuscript, warrant further investigation. Finally, it is important to remark the significance of continued reporting of the AEs to the pharmacovigilance registers (see Supplementary material), from which we derive additional info...
Another strategy to stop DNA transcription is to inhibit transcription factors (TFs). TFs are essential to RNApolII attachment to the DNA at the initiation step [143]. TF inhibitors (TFi) have already demonstrated their anti-tumor activity in clinical trials with the water-soluble pro-drug minn...
Examples of agonist MAbs in clinical trials US trade name (generic name)CompanyCurrent status (US)Molecular targetMajor IndicationProtein format CP-870893 Pfizer Phase II CD40 Oncology IgG Mapatumumab (HGS-ETR1) HGS Phase II DR4 (TRAIL-R1) (CD261) Oncology IgG Apolizumab (Hu1D10) NCI/...
has been investigated in phase 1 clinical trials in patients withStaphylococcus aureusbacteremia (NCT03162250). Non-cytotoxic payloads are also entering the payload landscape with the example of intracellular targeting of lipid metabolism by conjugating a Liver X Receptor (LXR) agonist to anti-CD11b...
Mitra S, Tomar PC (2021) Hybridoma technology; advancements, clinical significance, and future aspects. J Genet Eng Biotechnol 19:159 PubMed PubMed Central Google Scholar Hammers CM, Stanley JR (2014) Antibody phage display: technique and applications. J Invest Dermatol 134:1–5 PubMed Google...
Clinical relevance of CD70 expression in resected Pancreatic cancer: prognos- tic value and therapeutic potential. Pancreatology. 2021;21:573–80. 73. Qu CF, Li Y, Song YJ, Rizvi SM, Raja C, Zhang D, et al. MUC1 expression in primary and metastatic Pancreatic cancer cells for in vitro ...
Recently, T cells engineered with CD16 valine/CD28/CD3ζ, in combination with the anti-CD20 mAb rituximab were tested in a phase I clinical study of CD20-positive non-Hodgkin lymphoma. Its administration appears to be safe, as it is associated with limited cytokine release syndrome (CRS) and...
Inotuzumab ozogamicin, also known as CMC-544, consists of a humanized mAb targeting CD22 linked to a cytotoxic N‐acetyl-γ-calicheamicin with an average DAR of 5–7. CD22 is a cell surface antigen found in the majority (60–90%) of B-cell acute lymphoblastic leukemia (B-ALL).166,167...