auristatin‐based ADCbenzodiazepineDNA‐damaging agentsdrug‐linker chemistrymaytansinoid‐based ADCtubulysinsHan, Amy QRegeneron Pharmaceuticals, Inc. Tarrytown NY USAOlson, William CRegeneron Pharmaceuticals, Inc. Tarrytown NY USAJohn Wiley & Sons, Inc....
antibody–drug conjugatetargeted deliverycancer therapycombination therapyLiu, XinyuDepartment of Biomedical Engineering, School of Medicine Tsinghua University Beijing PR ChinaGao, WeipingDepartment of Biomedical Engineering, School of Medicine Tsinghua University Beijing PR China...
antibody‐drug conjugatebrentuximab vedotincancer‐selective cell surface moleculescombination chemotherapycytotoxic drug therapycytotoxic payloaddose‐limiting toxicitiesmetastatic HER2‐positive breast cancertumor cellsLambert, John MJohn Wiley & Sons, Inc....
ADC Antibody–drug conjugate PDC Peptide–drug conjugate FBS fetal bovine serum FDA U.S. Food and Drug Administration MTD maximal toxic dose CDR complementary determining region MMAE monomethylauristatin E LC–MS Liquid chromatography–tandem mass spectrometry MFI mean fluorescence intensity References Jan...
[17,18]. This suggests that SORT1 is a potentially therapeutic target for tumor therapy. Theratechnologies developed a SORT1-targeted peptide–drug conjugate (PDC)_TH1902 for the treatment of SORT1-positive triple-negative breast cancer [19]. TH1902 was generated by a conjugated TH1901 peptide...