Antibodies are secreted immunoglobulin molecules produced mainly by plasma cells. The antigen-binding site of the antibody has a unique structure that allows it to bind antigen in a highly specific manner. Latest Research and Reviews Validation of a multiplexed immunoassay for immunological analysis of...
Antigen to stimulate the body, produce immunological reaction, and secreted by plasma cells in the body and the synthesis of a group of immunoglobulin antigen specific binding capacity, which is immune globulin, this and the antigen binding specificity is the ability of antibody immunoglobulin. Peptid...
With a capture system for secreted proteins at hand, we established an antibody discovery workflow with primary immune cells. To determine cell survival in the hydrogel and optimal duration of antibody secretion, we isolated mouse bone marrow plasma cells (CD138+) by positive magnetic selection and...
For example, differentiation of B cells into antigen-secreting plasma cells is facilitated by the interaction of CD40 on B cells with CD40L on activated CD4+ T cells [11, 65]. Moreover, secretion of T-cell cytokines such as IL-2, IL-4, IL-5, IL-6, and IL-10 is important in ...
that is the consequence of the presence of IgA plasma cells in the immediate proximity of the secreting epithelial cells, facilitates the conjugation of the IgA molecules with the "transport" piece; in fact we could show, by immunofluorescence, a prevalence of IgA plasma cells at the level of...
For most, no cure is available, particularly when the pathogenic antibodies are secreted by long﹍ived plasma cells resistant to conventional immunosuppressive therapies. Current therapeutic approaches target not only the plasma cells that secrete pathogenic antibodies, but also those providing protective ...
Lifetime of plasma cells in the bone marrow. Nature 388, 133–134 (1997) Article ADS CAS Google Scholar Slifka, M. K., Antia, R., Whitmire, J. K. & Ahmed, R. Humoral immunity due to long-lived plasma cells. Immunity 8, 363–372 (1998) Article CAS Google Scholar Amanna, I....
It functions mainly as an antigen receptor on B cells that have not been exposed to antigens. The secreted form is associated with granulocytes and inflammation. It has been shown to activate basophils and mast cells to produce antimicrobial factors. IgE is derived from an IgY-like ancestor. ...
Estimation of the relative avidity of 19S IgM rheumatoid factor secreted by rheumatoid synovial cells for human IgG subclasses 19S IgM rheumatoid factors (RF) may play an important role in sustaining inflammation in rheumatoid arthritis (RA). As yet, no unique antigenic specificity... DL Robbins...
Certain antibody-secreting cells can be identified and recovered using the immunospot array assay on a chip, a cell-based microarray chip technique that enables the trapping of secreted antibodies by a chip coated in antibodies against Ig [148]. The procedure of micro-engraving, which produces mic...