Patients and methods: We immunoenzymatically measured anti-t-PA antibodies in plasma from 97 consecutive IBD patients and 97 ageand sex-matched healthy controls. We also assessed the antibody interactions with different epitopes of t-PA, the antibody inhibition on t-PA activity and the correlation...
Plasma free insulin was higher during treatment with glycerol-insulin than with the standard insulin treatment ( P < .02). Insulin antibodies increased in all patients ( P < .05). High-performance liquid HPLC analysis of insulin samples from the pump reservoirs showed the generation of insulin ...
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. Lancet 397, 2049–2059 (2021). Article Google Scholar Khoury, D. S. et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic...
et al. α-RgIA: a novel conotoxin that specifically and potently blocks the α9α10 nAChR. Biochemistry 45, 1511–1517 (2006). CAS PubMed Google Scholar Callaghan, B. et al. Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB ...
The detection limits for the SARS-CoV-2 IgM and IgG assays were determined by assaying a diluted lithium heparin plasma sample of a healthy individual in replicates of 20 and was calculated as 3 SD added to the mean response of the diluted sample. The diluted sample was prepared by mixing ...
Granulocytes are mobile and are attracted to foreign materials by chemical signals, some of which are produced by the invading microorganisms themselves, others by damaged tissues, and still others by the interaction between microbes and proteins in the blood plasma. Some microorganisms produce toxins ...
IgA+ plasma cells appear within the infarct between 2- and 4-weeks following stroke. • They persist for at least 7 weeks. • The appearance of IgA+ plasma cells in the infarct is T-lymphocyte independent. • The IgA+ plasma cells present in the infarct secrete natural antibodies. ...
responsive antibodies determining/altering the target protein function and hence the disease biology. The valid range of pH values in which such antibodies possess the potential to act as therapeutics spans the pH of acidified tumor microenvironment (TME, pH 5.9) and neutral human plasma (pH 7.4)...
Broadly neutralizing antibodies (bnAbs) develop in a subset of HIV-1 infected individuals over 2–3 years of infection. Infected infants develop plasma bnAbs frequently and as early as 1-year post-infection suggesting factors governing bnAb induction in
A cryo-EM reconstruction of a soluble Env trimer bound to 3BC315 Fab at 9.3 Å resolution reveals that the antibody binds between two gp41 protomers, and neutralizes the virus by accelerating trimer decay. In contrast, bnAb 35O22 binding to a partially overlapping quaternary epitope at ...