"ANTIBODIES, HEAVY AND LIGHT CHAINS, PHARMACEUTICAL COMPOSITION AND METHODS OF DETECTION OF THE OPGL LEVEL IN BIOLOGICAL AND TREATMENT SAMPLES". Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering pharmaceutically effective ...
RANDOM association of VL and VH repertoires contributes considerably to antibody diversity1. The diversity and the affinity are then increased by hypermutation in B cells located in germinal centres2. Except in the case of 'heavy chain' disease3, naturally occurring heavy-chain antibodies have not ...
RANDOM association of VL and VH repertoires contributes considerably to antibody diversity1. The diversity and the affinity are then increased by hypermutation in B cells located in germinal centres2. Except in the case of 'heavy chain' disease3, naturally occurring heavy-chain antibodies have not ...
The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish ( Cos5 -Abs) and nurse shark (NAR). To reveal the ...
et al. Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG. Nat. Commun. 6, 6113 (2015). CAS PubMed Google Scholar Smith, E. J. et al. A novel, native-format bispecific antibody triggering T cell killing of B cells is robustly ...
Our scientists have bioengineered the platform to minimize sequence liabilities and maximize the functional library space, with 90% of sequences encoding functional light and heavy chains. Antibodies derived from the Pioneer Platform show high homology to germline sequences, resulting in leads with high...
177. Neutralizing antibodies directed against botulinum neurotoxin types A and B heavy and light chainsBotulinum neurotoxins (BoNTs) are responsible for human botulism, a life-threatening disease characterized by flaccid muscle paralysis that occurs naturally by food poisoning or colonization of the ...
A major issue in engineering IgG-based bispecific antibodies has been to enable the correct association of heavy and light chains resulting in correct assembly of the desired bispecific antibody in sufficient yield. Various approaches have been described during recent years to tackle this challenge. ...
Heavy-chain only antibodies derived from dromedary are secreted and displayed by mouse B cells Whereas functional heavy (H)-chain antibodies devoid of light (L)- chains account for about half of the circulating immunoglobulins in Camelidae, H-chain o... VK Nguyen,X Zou,M Lauwereys,... - ...
An agonist antibody that specifically binds to Tie-2 comprising a heavy chain and a light chain, in which the framework regions of said heavy and light chains are derived from at least one selected antibody and the amino acid sequences of the regions of Determination of heavy chain complementar...