We evolved seven human immunoglobulin G (IgG) antibodies that bind to antigens from coronavirus, ebolavirus and influenza A virus. We focused on viral antigens given the importance of antibody therapeutics for viral diseases29,30,31,32. We improved the affinity of all antibodies after measuring ...
2 infection that recapitulates moderate disease in humans, primary infection clearly triggers GC formation, leading to protection from re-infection91,92. Finally, in a rare analysis of SARS-CoV-2-seropositive organ donors, virus-specific GCs have actually been found in the lung-associated lymph n...
2 Antigens Antigens are usually fairly large molecules or particles consisting of, or containing, protein or polysaccharides that are foreign to the vertebrate species into which they are introduced. Most have a molecular weight greater than 10 kDa, although smaller peptides can elicit antibody prod...
US5030718 Jan 10, 1990 Jul 9, 1991 Institut Pasteur Retrovirus capable of causing AIDS, antigens obtained from this retrovirus and corresponding antibodies and their application for diagnostic purposesUS5030718 Jan 10, 1990 Jul 9, 1991 Institut Pasteur Against htlc, in pure form...
Antibodies are produced by the body when B cells come in contact with a matching antigen. As a result, the B cell is activated and differentiates into a plasma cell that secretes large amounts of antibody. These antibodies are able to specifically bind the antigen which has caused the differe...
When the body is invaded by a pathogen, macrophages release the protein signals interleukin-1 (IL-1) and interleukin-6 (IL-6) to help fight the infection. One of their effects is to raise the temperature of the body, causing thefeverthat often accompanies infection. (The interleukins increa...
Now, there are different types of antigens, but, for our purposes here, let’s zoom in on foreign, disease-causing antigens. These are harmful substances that come from outside the body, such as from viruses or bacteria. The body wants to fight antigens off, so it recognizes these subs...
For some antigens (e.g. some integrins), multimerization is known to induce internalization; however, this data suggests that this is not the case with NTA lipomes bound to ErbB2. A (His)6-tagged EGFR-specific internalizable single chain Fv C10 (anti-EGFR-scFv-C10-(His)6) [38] ...
Antibody heavy chain variable region fragments (VHHs) are small (12-15 kDa) proteins that comprise specific binding regions to antigens. When introduced into an animal, VHHs bind and neutralise the effect of disease-causing agents in situ. Owing to their smaller mass, they are less ...
The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of pre...