Antibodiesare special protein molecules that the immune system produces in response to antigens. Andantigensare substances that can stimulate the body’s production of antibodies. Now, there are different types of antigens, but, for our purposes here, let’s zoom in on foreign, disease-causing ...
We evolved seven human immunoglobulin G (IgG) antibodies that bind to antigens from coronavirus, ebolavirus and influenza A virus. We focused on viral antigens given the importance of antibody therapeutics for viral diseases29,30,31,32. We improved the affinity of all antibodies after measuring ...
Antiphospholipid antibodies (aPL) are autoantibodies that bind to complex antigens including phospholipids and phospholipid-binding proteins, such as β2-glycoprotein I19. These autoantibodies cause thrombosis and recurrent pregnancy loss; and are the strongest maternal risk factor for preeclampsia, increasin...
Less abundant and less tightly bound antigens like e.g. some transcription factors or non-direct DNA binders that are part of larger complexes, can dissociate from DNA since they are not cross-linked. This is even more relevant for CUT&Tag due to the high salt concentration in the wash ...
In 1983 the detection of an IgA class antibody to antigens in monkey oesophagus was shown to have high sensitivity and specificity for coeliac disease. It proved to be an almost ideal test [127,128]. The antibody stained structures around muscle fibre bundles termed the endomysium and was th...
Baculovirus purified S protein (antigen S) is immobilized in the gap between interdigitated electrodes. Serum antibodies to the S protein bind to the S protein. Gold nanoparticles conjugated with protein G (GNP-proteinG) bind to the antibodies, causing an impedance change. The zoomed-in area ...
Retrovirus capable of causing AIDS, antigens obtained from this retrovirus and corresponding antibodies and their application for diagnostic purposesThe invention relates to a new variety of retroviruses designated human immunodeficiency virus type... L Montagnier,D Guetard,Francoise Brun-Vezinet,... -...
to target antigens and the number of sites bound42,43,44,45,46, we examined the density of mAb binding to the cell surface using the mean fluorescence intensity. Antibody-binding density was substantially lower for the non-protective mAbs compared to the protective mAbs Z11, Z15, Z18, ...
b) does not measurably bind to monomeric human M-CSF; and c) neutralizes the biological activity of human M-CSF as determined by the ability of the monoclonal antibody to inhibit M-CSF bioactivity in vitro. 2. The monoclonal antibody as described in claim 1, wherein said antibody binds to...
The T cell receptor for antigen (TCR) consists of two glycoproteins containing variable regions (TCR-alpha/beta or TCR-gamma/delta) which are expressed on ... Alarcón,S C,Ley,... - 《Embo Journal》 被引量: 130发表: 1991年 Cooperative Interactions of Simian Immunodeficiency Virus Nef, AP...