There are five generations of cephalosporins, with increasing expanded coverage across the class to include gram-negative infections. Newer generations with updated structures are developed to allow wider coverage of certain bacteria. Cephalosporins are bactericidal (kill bacteria) and work in a similar ...
Aminoglycosides may be used in combination with with penicillins or cephalosporins to ensure better antimicrobial coverage. Aminoglycosides work quite well, but bacteria can become resistant to them. Since aminoglycosides are broken down easily in the stomach, they can't be given by mouth and must ...
Drug Class: Anti-Staphylococcal ("Anti-Staph") PCNStructure: has BULKY R group --> creates MORE beta-lactamase resistance, BUT can't pass porins in GN bacteria Bacterial Coverage: GP with MORE Staph coverage-MSSA (including penicillin-susceptible S. aureus)-S. pyogenes and other strepotocci ...
with saline Closure of the abdomen Close monitoring SURGICAL INFECTION AND ANTIBIOTICS Peritonitis and Intraabdominal Abscess Antibiotic Therapy Usually empiric Rarely altered by culture data Should include anaerobic coverage SURGICAL INFECTION AND ANTIBIOTICS Peritonitis and Intraabdominal Abscess Duration of ...
NecrotizingSoftTissueandFascialInfection TreatmentAggressivesurgicaldebridementInitialempiricantibioticcoverageforStaph,Strep,EntericsincludingClostridiaTailorantibioticcoveragetocultureresultsSURGICALINFECTIONANDANTIBIO33SURGICALINFECTIONANDANTIBIOTICS ClostridiumDificileAssociatedDiarrheaMostcommoncauseofnosocomialdiarrheaonsurgicalunit...
% result in infection Treatment is with Augmentin Need to debride devitalized tissue Human Bites Staph, Stept, Eikenella, Bacteroides, Peptostrep Treatment is based on length of time from innoculation Augmentin, Unasyn Nasal and Sinus Surgery Current recommendations are to give anti- staph coverage...
*anaerobic coverage+RRlCloxacillinlOxacillinlNafcil 4、linlMethicillinlImipenem+Cilastatin(Primaxin)lMeropenem(Merrem)lErtapenem(Invanz)lVery broad spectrumlGram negative including pseudomonasl gram positive including staph and enterococcus lAnaerobeslIndicated for“high-severity”intra-abdominal infectionsl...
What types of bacteria are indicated for treatment with Nafcillin? Penicillinase producing staph (i.e. staph aureus) What are the pharmacokinetics/dynamics of Nefcillin? - Can only be through an IV- Poor absorption if given orally What are the adverse effects of Nefcillin? Allergic reaction (...
Chronic bacterial infections associated with biofilm formation are often difficult to resolve without extended courses of antibiotic therapy. Mesenchymal stem cells (MSC) exert antibacterial activity in vitro and in acute bacterial infection models, but
- Staph Aureus- Staph Epidermidis- Streptococcus Species Most likely pathogrsn associated with clean-contaminated - Skin Flora- Gram Negative Rods- Enterococci Species When surgery involves viscous, pathogens may reflect endogenous flora and infection may be ___ polymicrobial Antibiotics administered ...