Coverage bias in small molecule machine learning Fleming Kretschmer Jan Seipp Sebastian Böcker Nature Communications (2025) Explainable deep learning and virtual evolution identifies antimicrobial peptides with activity against multidrug-resistant human pathogens Beilun Wang Peijun Lin Yihan Wu Nature ...
The ARGs were related to tetracyclines, quinolones, β-lactam, and aminoglycosides, in accordance with the antibiotics widely used in the clinic for humans or animals. The emergence, prevalence, and differences in resistance genes in the intestines of yaks, beef, and dairy cattle may be caused ...
5, 19 Guideline concordant therapy was defined as triple coverage with both anti-MRSA and two anti-pseudomonal antibiotics which is different than our study. Similarly, we did not establish benefit with triple therapy in the interaction between CAP-resistance and treatment or in the ecological ...
it also displayed activity against four G-ve bacteria:N. gonorrhoeae,Neisseria meningitidis,M. catarrhalisandL. pneumophila[122]. It was also demonstrated that18was active against MSSA and MRSA biofilms, was active in topical in vivo models (though highly formulation-dependent) and that its MoA...
patients can present with: universal infection coverage, anaerobic infection coverage, pseudomonal infection coverage, MRSA infection coverage, non-MRSA gram-positive cocci infection coverage, gram-negative sepsis coverage, sinusitis infection coverage, pharyngitis infection coverage, and human bite coverage....
effective against a wide variety of organisms - MRSA cephalosporins side effects similar to penicillins - mild diarrhea, abdominal cramps, rash, pruritus, redness, edemapotential cross-sensitivity with penicillins (if true allergy exists)1-4% of patients will have a slight reaction severe ...
疼痛科中抗生素使用(英文)Antibiotics-and-Pain-Control课件.pptx,Examples of Operational Need Stimulating Scientific Innovation Antibiotics and Pain Control WW II • Poole, 1944: –“The greatest lesson learned from World War II may have been the benefit
While data on efficacy are limited, additional choices for gram-positive coverage in adults may also include daptomycin, telavancin, or ceftaroline. [22] In patients with sickle cell anemia and osteomyelitis, the primary bacterial causes are S aureus and Salmonellae species. Thus, the primary cho...
The need for new antibacterial drugs to treat the increasing global prevalence of drug-resistant bacterial infections has clearly attracted global attention, with a range of existing and upcoming funding, policy, and legislative initiatives designed to r
cephalosporin drug of choice for MRSA ceftaroline aztreonam general coverage aerobic gram negative, pseudomonas carbapenem general coverage gram positive, gram negative (pseudomonas), anaerobes carbapenem (specifically imipenam) a/e CNS toxicity vancomycin IV covers MRSA, gram positive vanc A/E red man...