Antibiotics that target multiple cellular functions are anticipated to be less prone to bacterial resistance. Here we hypothesize that while dual targeting is crucial, it is not sufficient in preventing resistance. Only those antibiotics that simultaneou
We found that critical Gram-negative pathogens develop resistance within a short time frame after antibiotic exposure in vitro. The mutations driving this resistance, found in laboratory-evolved strains, are already present in natural pathogen populations, suggesting that resistance can rapidly emerge thro...
Tetracyclines: decrease in effectiveness of penicillins Parenteral aminoglycosides: inactivation of aminoglycosides Sulfonamides Sulfonamides are drugs that inhibit folic acid synthesis. Therapeutic Action The desired and beneficial action of sulfonamides is: Inhibit folic acid synthesis required as precursors of...
There is growing global recognition that the continued emergence of multidrug-resistant bacteria poses a serious threat to human health. Action plans released by the World Health Organization and governments of the UK and USA in particular recognize that discovering new antibiotics, particularly those wi...
in 2019, with 1.27 million deaths directly attributed to, and 4.9 million deaths associated with, resistant bacteria [1]. The development of new antibiotics, particularly new chemotypes or classes that can overcome existing resistance mechanisms, has been hindered by a failure of the healthcare ...
In this context, it has been shown that ciprofloxacin affects P. falciparum by causing the formation of an abnormal apicoplast and a ‘delayed death’ of treated parasites [62]. Quinolones display anti-malarial activity, probably by targeting the gyrase of P. falciparum, an enzyme that is ...
Specifically, tetracycline, sulfathiazole, and ampicillin are representative antibiotics found in poultry wastewater. To degrade these refractory and impediment antibiotics more easily, a special method is needed, such as an enzyme method. This research used a special enzyme in an experiment that tested...
A novel peptide, 1403, improves the potentiation of rifampicin in vitro and in vivo and potentiates most Gram-positive antibiotics. The “sensitizer” approach is more plausible than those that rely on conventional drug discovery methods concerning drug development costs and the development of drug ...
Bacterial resistance to antibiotics is growing up day by day in both community and hospital setting, with a significant impact on the mortality and morbidity rates and the financial burden that is associated. In the last two decades multi drug resistant
Antibiotic misuse has alarmed the Chinese population because some antibiotics persist in the environment and adversely affect human health and other non-target organisms. Antibiotic priority setting has been considered the best monitoring tool that is also affordable and time-efficient. Therefore, this ...