Addressing the ongoing antibiotic crisis requires the discovery of compounds with novel mechanisms of action that are capable of treating drug-resistant infections1. Many antibiotics are sourced from specialized metabolites produced by bacteria, particul
Enough variation exists between the second generation cephalosporins in regard to their spectrums of activity against most species of gram negative bacteria, that susceptibility testing is generally required to determine sensitivity. The second generation includes: cefaclor cefamandole cefonicid ceforan...
Interestingly, at concentrations of 800 and 4000 μg ml−1 ZIF-67 did not affect the viability of the tested lung cells, whereas at a concentration of 8000 μg ml−1 ZIF-67 caused a ~50% loss of cell viability (Fig. 5c). Our results support that the ZIF-67 nanoparticles...
Preparation of cell extract is one of the key factors that affect the efficiency of the cell-free system. To improve the efficiency and economical feasibility of cell-free protein synthesis, we discussed...关键词: Gram-negative bacilli Lipopeptide Thiopeptide Structural sequence Antibiotic activity ...
Its chemical structure is similar to that of penicillin, but it has a broader spectrum of action and inhibits the activity of both gram-positive and some gram-negative bacteria. Semisynthetic derivatives (for example, cephaloridin) obtained from the “ring” of the cephalosporin molecule (7-...
Tetracycline is bacteriostatic and is active against gram negative and gram positive bacteria. Bacterial isolates of genera Moraxella, Pseudomonas, Flavobacterium, Vibrio, Xanthomonas, Alcaligens, Micrococcus, Aeromonas, and Acinetobacter were reported to have resistance against ampicillin (Olaimat et al.,...
Results: It was found that inappropriate gram-positive antibiotic use in ICUs was as high as 83% in terms of non- compliance with the selected quality parameters. Multivariate analysis was performed to evaluate the factors associated with inappropriate antibiotic use, increased creatinine levels were...
Preparation of cell extract is one of the key factors that affect the efficiency of the cell-free system. To improve the efficiency and economical feasibility of cell-free protein synthesis, we discussed...doi:10.1007/s10529-018-2589-1Xue Yun...
What makes gram negative bacteria more resistant to antibiotics? What is the antibiotic drug called Cipro? What medication is given for a carbapenem resistant UTI? How have antibiotic resistant strains of bacteria evolved? What is the virulence factor of E. coli?
. CAP belongs to the class of antibiotics which are effective against Gram-negative bacteria. However, due to the fact that antibiotics are selectively toxic, it can also inhibit prokaryotic and eukaryotic cells alike. CAPs mode of action is achieved through the inhibition of peptide bond ...