For example, the drug needed to treat multi-drug resistant Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, and Mycobacterium tuberculosis, can cost 100 times more than first generation drugs used to treat non-resistant forms. Most worrisome is that resistance to virtually all ...
The nationwide incidence of group A streptococcal bacteremia in Sweden was 1.8 per 100,000 population in 1987. During the winter season 1988-1989, the repo... Anders Strmberg,V Romanus,LG Burman - 《Journal of Infectious Diseases》 被引量: 402发表: 1991年 Hyperendemic Streptococcus pyogenes ...
JNJ-Q2is a fluorinated 4-quinolone developed for the treatment of acute bacterial SSTI and respiratory tract infections. In a recent study involving 118 isolates ofStreptococcus pneumoniae, including fluoroquinolone-resistant variants, it was 32-fold more potent than moxifloxacin. It has also shown a ...
It completed a phase-II trial for ABSSSi in 2012 (NCT01119105).159 BC-3781 (28) is a protein synthesis inhibitor and displays antibacterial activity against skin and respiratory pathogens such as S. aureus, Enterococcus faecium, Streptococcus pneumoniae, Haemophilus influenzae, C. difficile, ...
Carbavance Biapenem RPX7009 Phase 3, Rempex Pharmaceuticals Complicated urinary tract infections, complicated intra-abdominal infections, hospital-acquired-/ventilator-associated bacterial pneumonia, febrile neutropenia, bacteremia, acute pyelonephritis a It also includes Cilastatin, an inhibitor of the human...
G. Cost-effectiveness of daptomycin versus vancomycin and gentamicin for patients with methicillin-resistant Staphylococcus aureus bacteremia and/or endocarditis. Clin. Infect. Dis. 49, 691–698 (2009). Article CAS PubMed Google Scholar Mossialos, E. et al Policies and Incentives for Promoting ...
Twenty-nine infants had meningitis, 66 had bacteremia (37 with concomitant urinary tract infection), and 170 had urinary tract infection alone. No methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus sp., or penicillin-resistant Streptococcus pneumoniae were identifi...
for acute bacterial skin and skin structure infections (ABSSSI) that led to FDA approval in May 2014 for treatment of G+ve ABSSI infections in adult patients caused by susceptible isolates ofStaphylococcus aureus(including methicillin-susceptible and methicillin-resistant strains),Streptococcus pyogenes,...
RESULTS: A total of 575 clinical episodes were identified, and Streptococcus pneumoniae (n = 109), Neisseria meningitidis (n = 96), and Staphylococcus aureus (n = 89) were commonly isolated. The rate of bacteremia was 1.42 per 1000 ED attendances (95% confidence interval: 1.31-1.53). ...
DNA polymerase IIIC, which is a new target for clinical development, is an essential enzyme in low guanine and cytosine classes of bacteria such as Bacillus, Clostridioides, Enterococcus, Mycoplasma, Lactobacillus, Listeria, Pneu- mococcus, Staphylococcus and Streptococcus. The dis- covery of ACX...