Strains producing 尾-lactamase with extended spectrum (ESBL and AmpC) were also found in these isolates. Enterococcus spp. displayed resistance to norfloxacin and ciprofloxacin, and some isolates were resistant to vancomycin, gentamicin and streptomycin (complementary tests). No P. aeruginosa resistant ...
Wang WL. Study on the antibacterial mechanism of herbal extracts and drug resistance of E. coli[D]. Baoding: Master's Thesis of Agricultural University of Hebei, 2015 (in Chinese)http://www.wanfangdata.com.cn/details/detail.do?_type=degree&id=Y2874610. Google Scholar [13] Novo D, Pe...
However, their effectiveness and accessibility has led to overuse and, in recent years, consequent antibiotic resistance. Antibiotics are divided into classes based upon their method of production or bactericidal method of action. They may be produced b...
Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for an...
We review these compounds to provide inspiration for the design of much-needed new antibacterial agents, and examine the complex mechanisms that have evolved to effectively target bacteria, including covalent binders, inhibitors of resistance, compounds that utilize self-promoted entry, those that evade...
OBJECTIVE To analyze the resistance of Enterobacter cloacae AmpC β-lactamase with/without being induced by imipenem(IMP),cefepime(FEP),ceftriaxone(CRO) and aztreonam(ATM).The ampD genes of mutant strains were sequenced. METHODS Five wild type strains and 5 hyper-inducible type strains of E.cloac...
The effectiveness of antibiotic agents depends on many factors such asroute of administration, location of infection, presence of interfering substances, concentration of the drug in the body, nature of the pathogen, presence ofdrug allergiesand resistance of microorganism to the drug[5]. The effecti...
increased through structural modifications and by engineering polyvalent drugs and combination therapies designed to overcome drug-resistance mechanisms. Finally, we examine the regulatory and translational challenges for antibiotic re-engineering, highlighting the need for antibiotic stewardship and global ...
Knowing the optimal duration of antibiotic therapy for pneumonia is crucial for effective antimicrobial stewardship. This is especially important as concerns mount over rising antibiotic resistance in respiratory bacterial pathogens, which increases the risk of treatment failure. Numerous studies have focused...
Antimicrobial resistance Nature Reviews Microbiology(Nat Rev Microbiol) ISSN1740-1534(online) ISSN1740-1526(print) Sign up for theNature Briefing: Microbiologynewsletter — what matters in microbiology research, free to your inbox weekly. Email address ...