By demonstrating in detail how the HipA protein freezes bacterial activity, the researchers have opened the possibility of adding a new class of drugs to therapy against chronic and multidrug resistant bacterial infection. Working in Escherichia coli, the team solved the structure of HipA and several...
E. Coli Persists Against Antibiotics Through HipA Induced Dormancy
coli, verified using both optical density measurement of bacterial cultures in 96 well plates and a luminescent ATP activity assay. The bactericidal effects of DEA-NONOate against E. coli is proof-of-concept to pursue evaluation of nitric oxide-based formulations as antimicrobial and antiviral ...
Synergistic interactions of vancomycin with different antibiotics against Escherichia coli: trimethoprim and nitrofurantoin display strong synergies with vancomycin against wild-type E. coli. Antimicrobial Agents Chemother. 2015;59:276–81. Article CAS Google Scholar Baker SJ, Payne DJ, Rappuoli R, De...
The word antibiotic means “against life.” Any drug that kills germs in your body is technically an antibiotic, but most people use the term when they’re talking about medicine that kills bacteria. History of antibiotics Scientists introduced the first antibiotic, salvarsan, in the early 1900...
The new methods show promise in the discovery of novel gene-specific antisense antibiotics that will be useful in the future battle against drug-resistant bacterial infections. This review describes this promising paradigm, the targets that have been identified and the recent technologies on which it...
Another member of the same family of genes, lly, which is required for production of the hemolytic pigment in Legionella pneumophila, also conferred production of turbomycin A and B on E. coli. We further demonstrated that turbomycin A and turbomycin B are produced from the interaction of ...
Mode of antimicrobial action of vanillin against Escherichia coli, Lactobacillus plantarum and Listeria innocua. J Appl Microbiol 2004;97:104–13. https://doi.org/10.1111/j.1365-2672.2004.02275.x.Search in Google Scholar PubMed 205. Togashi, N, Inoue, Y, Hamashima, H, Takano, A. Effects...
The advent of modern antibiotics contributed enormously to the dramatic extension of human lifespan since their discovery by virtue of their lethal and selective action against pathogenic microbes. And yet despite our powerful arsenal of weapons against these pathogens, the war against them has not be...
Parker, E. N. et al. Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens. Nat. Microbiol. 5, 67–75 (2020). CAS PubMed Google Scholar Durand-Reville, T. F. et al. Rational design of a new antibiotic class for drug-resistant infec...