Consumption of antibiotics causes a short-term shift to the FAMP resistotype We used existing time series data from healthy individuals in a controlled antibiotic trial11to explore the short-term dynamics of resistotype classifications. In this study, twelve men received a cocktail of three last-...
Craig wherein it revealed that long-term and low-dose use of the antibiotic trimethoprim-sulfamethoxazole (TMP-SMX) minimizes urinary tract infections (UTI) in children who are susceptible. ...
The compounds, which we term ‘antibiotic-chemoattractants’, consist of a formylated peptide (known to act as chemoattractant for neutrophil recruitment) that is covalently linked to the antibiotic vancomycin (known to bind to the bacterial cell wall). We use a combination of in vitro assays, ...
As such, the distribution pattern of antibiotic contamination and resistance determinants in various rivers worldwide has been described with a note of its long term impact. The information presented in this review may be useful to policy makers, clinicians, and pharmaceutical companies to tackle the...
during their hospital stay is defined as an ‘antibiotic patient’. The term ‘antibiotic’ is used for ‘anti-infectives for systemic use’ (antibacterials-J01 and anti-mycobacterials-J04), as classified by World Health Organization Collaborating Center for Drug Statistics Methodology [26] (WHO...
Although both the fecal and salivary microbiomes were acutely disrupted by antibiotics as measured by Bray-Curtis dissimilarity, no differences persisted at 1 year suggesting long-term stability and resilience to perturbation. An alternative explanation, however, is that the microbiome is meta-stable...
Although VLBW premature infants are at higher risk of early-onset infection compared with term-born infants, we found an overall rate of antibiotic initiation that was an order of magnitude higher than the actual incidence of infection5,29,30 and little change in antibiotic use over a ...
One of them, given at a high dose, could eliminate it completely, according to the study. "After four days, that compound can completely clear the infection, and that was quite surprising and exciting because we don't typically see that with other experimental antimicrobials or other antibiotic...
Although the risk of emergence and evolution of genetically inheritable antibiotic resistance in bacterial biofilms is likely underestimated, such events have been described during the long-term or repeated antibiotic treatments of chronic biofilm-related infections, suggesting that these treatments could ...
Many of the individuals in the cohort of the study by Köhler-Forsberg et al., had severe infections, including, central nervous system (CNS) infections, urological infections, or sepsis25. These infections often require long-term treatment with antibiotics26,27. Given the high occurrence of ...