Chi-Hung Lin4, Po-Ren Hsueh6, Juen-Kai Wang5,7 &Yuh-Lin Wang5,8 Rapid bacterial antibiotic susceptibility test (AST) and minimum inhibitory concentration (MIC) measurement are important to help reduce the widespread misuse of antibiotics and alleviate the growing drug-resistance problem...
pylori culture and antibiotic susceptibility testing. Figure 1. Flow chart of regimen modification based on H. pylori antibiotic resistance. HP, H. pylori; VACM, 14-day concomitant therapy consisting of vonoprazan, amoxicillin, clarithromycin, and metronidazole; VAM, 14-day triple therapy consisting...
Ideally, the doctor should receive susceptibility information the same day the culture is taken, since it is usually necessary to initiate therapy immediately. Unfortunately, it currently takes one day to isolate an organism, and it has required another day to test the susceptibility of the ...
Antibiotic treatment kills a large portion of a population, while a small, tolerant subpopulation survives. Tolerant bacteria disrupt antibiotic efficacy and increase the likelihood that a population gains antibiotic resistance, a growing health concern.
Bacteria within mature biofilms are highly resistant to antibiotics than planktonic cells. Oxygen limitation contributes to antibiotic resistance in mature biofilms. Nitric oxide (NO) induces biofilm dispersal; however, low NO levels stimulate biofilm fo
The development of new tools should be encouraged to help clinicians not to treat patients with antibiotics when bacterial infection is ruled out or, conversely, to help them to prescribe the right antibiotic through rapid identification of the bacteria involved and its antibiotic susceptibility. Re-...
Evolution of microbial traits depends on the interaction of a species with its environment as well as with other coinhabiting species. However, our understanding of the evolution of specific microbial traits, such as antibiotic resistance in complex envi
The development of new tools should be encouraged to help clinicians not to treat patients with antibiotics when bacterial infection is ruled out or, conversely, to help them to prescribe the right antibiotic through rapid identification of the bacteria involved and its antibiotic susceptibility. Re-...
Similarly, IS-related inversions and transpositions frequently disrupted genes with known influence on antibiotic susceptibility. For instance, loss-of-function mutations in the NADPH nitroreductase genes (nfsA and nfsB) cause resistance to nitrofurantoin and related agents21. These genes were disrupted ...
we conducted susceptibility test of these isolates to 20 antibiotics from 7 different classes, and found that all the isolates showed resistance to at least one of the used antibiotics (Supplementary Data4). Among the 485 isolates with dependable antibiotic susceptibility outcomes (each test was vali...