Narrowing antibiotic spectrum of activity for trauma-associated pneumonia through the use of a disease-specific antibiogrampneumoniaepidemiologyinfectionsBackground Organism susceptibilities for trauma-associated pneumonia (TAP) differ from those in other patient populations, including the critically ill. The ...
In addition, the antibacterial spectrum of activity and pharmacological properties of the natural penicillins can be changed and improved by these chemical modifications. The addition of a β-lactamase inhibitor, such as clavulanic acid, to a penicillin dramatically improves the effectiveness of the ...
Table 1 Spectrum of activity of MCPs against selected Gram-positive and Gram-negative bacterial species andC. albicans Full size table RO7075573 was found to be 4- to 64-fold more potent than RO7036668 against a panel ofA. baumannii, and displayed improved selectivity againstAcinetobacter(MIC ...
Furthermore, eICU represents a more unwell population given the higher proportion of life-threatening infections such as sepsis. Table 1 Dataset demographics and statistics Full size table The antibiotic spectrum index (ASI)25 demonstrates if an antibiotic treatment regime shows broad or narrow activity...
1). How the microbiome responds to antibiotics is altered by the state of the microbiome at the time of perturbation (diet, species, and functional diversity and redundancy) and the strength of the perturbation (route, spectrum, and duration of antibiotics). After cessation of antibiotics, the ...
Tetracyclines are broad-spectrum antibiotics with activity against aerobic and anaerobic gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and spirochetes. From:Feigin and Cherry's Textbook of Pediatric Infectious Diseases (Sixth Edition),2009 ...
Its spectrum of activity is similar to that of vancomycin, with excellent activity against Gram positive pathogens, including many resistant strains, such as MRSA[9]. Its major value is that it provides a therapeutic option for infections caused by vancomycin-resistant Enterococcus faecium, VISA or...
In this respect, most of the LAB of aquatic origin tested in this work displayed a broad antimicrobial spectrum against the main Gram-positive and Gram-negative fish pathogens, being remarkable that a high number of strains (24 out of 49 strains, 49%) were identified as potential bacteriocin ...
Here we report the structure-guided design and component-based synthesis of a rigid oxepanoproline scaffold which, when linked to the aminooctose residue of clindamycin, produces an antibiotic of exceptional potency and spectrum of activity, which we name iboxamycin. Iboxamycin is effective ...
Define Broad-spectrum antibiotic. Broad-spectrum antibiotic synonyms, Broad-spectrum antibiotic pronunciation, Broad-spectrum antibiotic translation, English dictionary definition of Broad-spectrum antibiotic. n. A substance, such as penicillin or erythr