Our understanding of the molecular mechanisms of resistance has recently increased as a result of advances in systems biology, genomics and structural biology. New knowledge about antibiotic resistance should be used to inform the design of novel therapeutic agents that might not be subject to, or ...
This study provided evidence of the trade-off between antibiotic resistance and desiccation tolerance, driven by condition-dependent adaptation, and establishes rationale for research into the genetic basis of the variation in fitness cost between clinical and environmental isolates [16]. In this study,...
Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study A bacterial gene (neo) conferring resistance to neomycin-kanamycin antibiotics has been inserted into SV40 hybrid plasmid vectors and introduced into cultu... KK ...
Credit: CC0 Public Domain Antibiotic-resistant bacteria are a growing problem in health care globally. To prevent further development of resistance, it is important to understand where and how antibiotic resistance in bacteria arises. New research from Uppsala University shows that low concentrations of...
Fitness cost of VanA-type vancomycin resistance in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 53, 2354–2359 (2009). In this important paper, the authors demonstrate that the fitness cost of the VanA-type glycopeptide resistance cassettes that are carried by clinical ...
新型污染物抗生素抗性基因(Antibiotic resistance genes,ARGs)对公共健康产生了严重威胁,其在水环境中的长期存在和传播引起了广泛重视.胞内与胞外ARGs在水环境中的分... 王敏妍,李亚丽,邹世春,... - 《分析测试学报》 被引量: 0发表: 2021年 土壤环境中抗生素抗性基因污染研究进展和热点分析 In recent years, ...
Cell wall antibiotics are crucial for combatting the emerging wave of resistant bacteria. Yet, our understanding of antibiotic action is limited, as many strains devoid of all resistance determinants display far higher antibiotic tolerance in vivo than s
Environmental antibiotic resistance has drawn increasing attention due to its great threat to human health. In this study, we investigated concentrations of antibiotics (tetracyclines, sulfonamides... 关键词: Antibiotic resistance genes Antibiotics Bacterial community composition Pathogens Fish ponds DOI: 10...
Previous studies reported microplastics (MPs), antibiotics, and antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs). There is still a lack of research progress on the origin, fate, impact and hazards of MPs and ARGs in WWTPs. This p
Finally, future research is proposed to fill the current knowledge gaps, which include mechanisms for the development and transmission of antibiotic resistance, as well as efficient treatment approaches for antibiotic resistance. Copyright 2021. Published by Elsevier B.V. 展开 关键词: ARGs Antibiotic ...