Here we investigated the effect of WWTP effluent on the abundance of the sulfonamide resistance genes sull and sul2, and the integrase gene intll in biofilm and surface water compartments of a river in Germany with a gradient of anthropogenic impact using quantitative PCR. Further...
Our findings suggest a possible mechanism for how cells within a population could achieve a gradient of resistance levels in a transient fashion. Cells that stochastically express higher levels of MarA may transiently turn on more downstream genes than those with low levels of MarA, leading to ...
Antibiotic treatment generally results in the selection of resistant bacterial strains, and the dynamics of resistance evolution is dependent on complex interactions between cellular components. To better characterize the mechanisms of antibiotic resista
Antibiotic diffuses outwards from each disc into the surrounding agar and produces a diminishing gradient of concentration. On incubation, the bacteria grow on areas of the plate except those around the drugs to which they are sensitive. The width of the zone of inhibition is a rough measure ...
Spatial and temporal variability in epilithic biofilm bacterial communities along an upland river gradient Riverine biofilms remain one of the least-studied habitats despite the significant increase in the examination of aquatic microbial communities in recent y... MJ Anderson-Glenna,B Vegar,NJW Clips...
antibiotic resistance, as structured bacterial communities can provide antibiotic protection due to antibiotic degradation [31], biofilm formation [32] or horizontal gene transfer [33]. In this work, we investigated the genetic determinants of antibiotic resistance by shotgun sequencing of marine ...
Efflux is a common mechanism of resistance to antibiotics. We show that efflux itself promotes accumulation of antibiotic-resistance mutations (ARMs). This phenomenon was initially discovered in a bacterial swarm where the linked phenotypes of high efflux and high mutation frequencies spatially segregated...
the impact of contaminants on human health, i.e., adverse effects on human health coming from the other two One Health “compartments”. It is recurrently claimed that antibiotic resistance must be approached from a One Health perspective, but such statement often only refers to the connection ...
Chlorine disinfection promotes the exchange of antibiotic resistance genes across bacterial genera by natural transformation Article Open access 23 April 2020 The role of chemotaxis and efflux pumps on nitrate reduction in the toxic regions of a ciprofloxacin concentration gradient Article 29 April 202...
The pathogen Staphylococcus aureus can readily develop antibiotic resistance and evade the human immune system, which is associated with reduced levels of neutrophil recruitment. Here, we present a class of antibacterial peptides with potential to act both as antibiotics and as neutrophil chemoattractant...