Antibiotic resistanceis a growing public health threat; resistant bacteria are responsible for over 2.8 million infections and over 35,000 deaths annually (CDC, 2019). Antibiotic use is a well-known driver of the development of resistance.
Our understanding of the molecular mechanisms of resistance has recently increased as a result of advances in systems biology, genomics and structural biology. New knowledge about antibiotic resistance should be used to inform the design of novel therapeutic agents that might not be subject to, or ...
43,44. To assess the antibiotic resistance profiles of thisE. colicollection, we conducted susceptibility test of these isolates to 20 antibiotics from 7 different classes, and
antibiotic resistance, by delaying effective healthcare, often leads to longer hospital stays, higher medical costs, and increased mortality. If antibiotic resistance is an old phenomenon that occurs naturally, misuse of antibiotics in humans and animals is accelerating the process. New resistance ...
Leading articles. Antibiotic resistanceFinchRGingentaconnectJournal of Antimicrobial Chemotherapy
Transmissible Resistance Due to Acquisition of Antibiotic Resistance Genes 1. Antibiotic resistance genes generally have little effect on the host cell's overall fitness. For example, many of these genes actually destroy the antibiotic and do not alter the target site. Further, the expression of som...
Antibiotic resistance, Poultry, Cattle, Diarrheal patients INTRODUCTION Campylobacter jejuni (C. jejuni) is one of the major causes of bacterial gastroenteritis in both developed and developing countries[1-3]. People become infected by consuming contaminated food, particularly poultry meat, raw mil...
Importantly, mice with micronutrient deficiencies also exhibited a higher enrichment of genes that have been linked to antibiotic resistance. “Micronutrient deficiency has been an overlooked factor in the conversation about global antibiotic resistance,” said Dr. Paula Littlejohn, a postdoctoral res...
Antibiotic-resistant Acinetobacter baumannii is associated with nosocomial infections worldwide. Here, we used clinically isolated A. baumannii strains as models to demonstrate whether antibiotic resistance is correlated with an increased susceptibility
Bacterial antibiotic resistance is a global health concern of increasing importance and intensive study. Although biofilms are a common source of infections in clinical settings, little is known about the development of antibiotic resistance within biofi