The spread of antibiotic resistance is attracting increased attention to combination-based treatments. Although drug combinations have been studied extensively for their effects on bacterial growth1–11, much less is known about their effects on bacteria
1 µg/ml (B), 4 µg/ml (C) and 8 µg/ml (D) imipenem was inoculated with either ancestralP. aeruginosaPA01 (blue),S. maltophilia(red) or no bacteria (black) and incubated for 48 h. Cultures were sampled at 8 h...
The researchers are trying to find a molecule capable of mimicking the final compound which boosts the action of the antibiotic in killing bacteria like E. coli, in a hope for designing new drugs for attacking E. coli in a more effective way....
These functionally validated ARGs present in the original fecal samples encode for proteins, the majority of which had not been previously ascribed resistance mechanisms in curated databases [54, 68]. Greater than 40% of these ARGs derive from E. coli, Enterobacter spp., and Klebsiella spp., ...
Hypothermic preservation of boar semen is considered a potential method for omitting antibiotics from insemination doses, thereby contributing to the global antibiotic resistance defence strategy. The main challenges are chilling injury to spermatozoa and bacterial growth during semen storage leading to redu...
However, as the disc diffusion method would not differentiate strains with reduced susceptibility to vancomycin (MICs 4 to 8 μg/mL) from susceptible strains, the MIC was determined using the E-test to test for the presence of any isolate with decreased susceptibility to the antibiotic. The ...
- An increase in global resistance rates in many bacterial species responsible for both community- and healthcare-related infections, e.g., staphylococci, enterococci, gonococci, and enterobacteria (including E. coli, Salmonella spp and Shigella spp), Pseudomonas spp, Acinetobacter spp, and Mycobact...
The report shows that bloodstream infections due to resistant E. coli, Salmonella and gonorrhoea increased by at least 15 percent compared to 2017. More research is required to identify how this is related to increased hospitalizations and antibiotic treatments during the COVID-19 pandemic, the WHO...
Table S3. Antibiotic-Resistant CDC Strains Used for Halicin Efficacy Assays, Related to Figure 3 Table S4. Whole Transcriptome Sequencing of E. coli Treated with Halicin, Related to Figure 4 Table S5. Prediction Scores and Optical Density Values of the Top 200 (Yellow) and Bottom 100 (Blue)...
jejuni/C. coli databases. Antibacterial Susceptibility Testing Commercial kits (Zhongchuang Biotechnology Ltd. Corp., Qingdao, China) were used to determine the minimum inhibition concentration (MIC) of all C. jejuni isolates. The agar dilution method was used[21], and the breakpoints used for ...