Method:In this comprehensive prospective study, a total of 410 multi-use topical eye medications containing 15 different ingredients from 22 pharmaceutical companies used by 185 patients were analyzed. Four groups were formed as follows: group 1: antibiotic ointments (n: 109); group 2: antibiotic ...
Nystatin is an ionophore that dissolves in the fungal cell membrane and increases the membrane’s permeability. This results in leakage of fungal cell contents and destruction of the fungus. Nystatin binds to ergosterol, a sterol in the fungal cell membrane that functions similar tocholesterolin hu...
Transdermal or rectal delivery, as well as application in the eye, may be appropriate in some cases.It may be advantageous for the substances according to the invention to be administered more effectively by advanced drug delivery or targeting methods. Thus, if the digestive tract is to be ...
Direct application of the lytic enzyme/polypeptide(s) may be by any suitable means to directly bring the polypeptide in contact with the site of infection or bacterial colonization, such as to the nasal area (for example nasal sprays), dermal or skin applications (for example topical ointments ...
Typical forms specified are petrolatum type grease base and polyethylene glycol water-soluble base ointments, creams, water-in-oil emulsions, lotions, ear drops, eye drops, aerosols,
An estimated 77% of these drugs are intended for oral administration (i.e. tablets, syrup and capsules), 17% are formulated for parenteral administration and the remaining are either eye drops or ointments dosage forms [81]. These products are used to treat people with serious infections among...