Over the last few decades several antibacterial peptides have successfully approved as drug by FDA, which has prompted an interest in these antibacterial peptides. In our recent study we analyzed 999 antibacterial peptides, which were collected from Antibacterial Peptide Database (APD). We have ...
We also found that the peptide made from all D-amino acids was more active than the corresponding L-enantiomer. MATERIALS AND METHODS Peptide design and synthesis The NY15 was constructed using Antimicrobial Peptide Database (APD: http://aps.unmc.edu/AP/ main.html) based on the Leucrocin I...
used by the host to protect itself from different types of pathogenic bacteria. Over the last few decades, the search for new drugs and drug targets has prompted an interest in these antibacterial peptides. We analyzed 486 antibacterial peptides, obtained from antimicrobial peptide database APD, ...
Molecular engineering of antimicrobial peptides: microbial targets, peptide motifs and translation opportunities Priscila Cardoso Hugh Glossop Celine Valery Biophysical Reviews (2021) In Silico Discovery of Novel Ligands for Antimicrobial Lipopeptides for Computer-Aided Drug Design Satya Eswari Jujjavarapu...
The antimicrobial peptide database (APD, http://aps.unmc.edu/AP/main.php) has been updated and expanded. It now hosts 1228 entries with 65 anticancer, 76 a... G Wang,X Li,Z Wang - 《Nucleic Acids Research》 被引量: 1264发表: 2009年 Improved Derivatives of Bactenecin, a Cyclic Do...
The searches were performed against a SwissProtein database. For taxonomy, “Viridiplantae” was specified. The probability of random hits (p) was set <0.05, meaning 95% confidence in the correct peptide identification. The peptide mass and the fragment mass tolerance were set at 1.2 Da. The ...
PURPOSE:To antibacterial base composition having improved activity, and containing N-acyl hydrolyzed peptide and an antibacterial agent. CONSTITUTION:A composition containing (A) N-acyl hydrolyzed peptide (the carbon number of the acyl group is 8-20 and the molecular weight of the hydrolyzed peptide...
The peptides detected by MALDI TOF/TOF did not show sufficient homology (<30%) with the database proteins. Circular dichroism spectroscopy suggested a disordered conformational structure, and fluorescence spectrum showed the presence of tyrosine residues in the hydrophobic core. The hemagglutinating ...
There is also high interest in identifying antiviral peptides. Some antimicrobial peptides are known to have antiviral effects. In the APD database [8], [9], 138 entries are annotated to possess antiviral activity as of October 2013. Human LL-37, but not a scrambled sequence, is potent ag...
et al. Peptide deformylase as an antibacterial drug target: target validation and resistance development. Antimicrob. Agents Chemother. 45, 1058–1064 (2001). CAS PubMed PubMed Central Google Scholar Margolis, P. S. et al. Peptide deformylase in Staphylococcus aureus: resistance to inhibition is...