Side effects, the most common of which were photosensitivity and gastrointestinal upsets, occurred in 44 per cent and were sufficiently severe to warrant withdrawal of treatment in 15 per cent. These results confirm that amiodarone is of considerable value in the treatment of recurrent paroxysmal ...
atrial flutter and fibrillation (acute termination) activates slow inward Na+ currents during early phase 3 and inhibits opening of repolarizing K+ channels, which delays repolarization and increases ERP; IV only; can cause life-threatening ventricular arrhythmias; infrequent non-cardiac side effects ...
On the contrary, based on multicentric clinical trials, it is now evident that serious side effects may considerably limit the use of currently available antiarrhythmic agents to abolish or prevent atrial fibrillation and life threatening ventricular tachycardias. Therefore, it seems worthwhile to review...
Use of antiarrhythmic drugs in the ICD patient population not only can cause potentially serious side effects but can also interact or interfere with the ICD device function. In addition, the effect on survival in patients with ICDs is not well characterized. Given the many potential side effects...
Effects of physical exercise on central nervous system functions: A review of brain region specific adaptations. J. Mol. Psychiatry 2015, 3, 3. [Google Scholar] [CrossRef] [Green Version] Cheedipudi, S.M.; Hu, J.; Fan, S.; Yuan, P.; Karmouch, J.; Czernuszewicz, G.; Robertson...
Their most important side effects are proarrhythmia and inducing torsades de pointes. With introduction of newer antiarrhythmic agents, INa blockers are less frequently used. INa currents are controlled and modulated by several genes and the most common being the SCN5A gene. Mutations in SCN5A ...
Both of these have significantly fewer side effects and are better tolerated. Currently there is little clinical data regarding their efficacy in chronic pain states. Newer antidepressants do not appear to be significantly better than placebo in treating pain. Their faster onset and fewer side ...
Side effects were observed in only eight patients (14 percent) and were primarily anticholinergic in nature. Transient hypotension, not necessitating treatment with pressor agents, was observed in three patients (5 percent), in two of whom discontinuance of therapy with disopyramide was deemed ...
The ideal choice won't cause side effects that damage the quality of life, nor will it worsen any concurrent disease. Although this ideal can't always be achieved, today's great variety of antiarrythmic agents provides effective and safe therapy in most ca...
Its effectiveness in therapy-resistant ventricular arrhythmias and its long duration of action with no important side effects at therapeutically effective dosage might make QX-572 a valuable antiarrhythmic drug.doi:10.1136/hrt.36.8.811Ryden, L