Cardiac arrhythmias remain a common cause of death and disability. Antiarrhythmic drugs (AADs) and antiarrhythmic agents remain a cornerstone of current ca
Antiarrhythmic drugs comprise many drug classes and have several mechanisms of action. Some classes and even some specific drugs within a class are effective with only certain types of arrhythmias. Therefore, attempts have been made to classify the different antiarrhythmic drugs by mechanism. Although ...
The long and growing list of non-antiarrhythmic drugs associated with prolongation of the QT interval of the electrocardiogram has generated concern not only for regulatory interventions leading to drug withdrawal, but also for the unjustified view that QT prolongation is usually an intrinsic effect of...
Table 1 List of the leading-edge genes over-expressed in prostate CAFs, corresponding encoded protein, regulated cation and antiarrhythmic drugs used to block them Full size table Activated fibroblasts show increased membrane conductance for potassium, sodium and calcium Electrophysiological recordings were...
Antiarrhythmic therapy during cardiac arrest electrical defibrillation and antiarrhythmic drugs Summary The success rate of cardiopulmonary resuscitation in patients with cardiac arrest due to ventricular fibrillation is predominantly determined by early de-fibrillation. Biphasic shocks appear superior as compared ...
More detailed information on specific drugs can be found at www.rxlist.com. Class IA: atrial fibrillation, flutter; supraventricular & ventricular tachyarrhythmias quinidine* anticholinergic (moderate) cinchonism (blurred vision, tinnitus, headache, psychosis); cramping and nausea; enhances digitalis ...
the margin of safety with these drugs as a group is narrow, clinically significant interactions may develop whenever the activity or plasma concentration of anantiarrhythmic agentis altered. The following discussion provides an illustrative but not exhaustive list of interactions involving these drugs. ...
The long and growing list of non-antiarrhythmic drugs associated with prolongation of the QT interval of the electrocardiogram has generated concern not only for regulatory interventions leading to drug withdrawal, but also for the unjustified view that QT prolongation is usually an intrinsic effect of...
The Catheter Ablation versus Anti-arrhythmic Drugs for Ventricular Tachycardia (CAAD-VT) trial will help determine whether catheter ablation is superior to antiarrhythmic drug therapy alone, in patients with SHD-related VT. Trial Registry Australian New Zealand Clinical Trials Registry (ANZCTR) Trial Re...
Because drugs such as ibutilide, dofetilide, sotalol and amiodarone suppress IKrby binding to the intracellular face of the potassium channel, drug access is limited (or enhanced) by the necessity of the drug to cross cell membranes to reach their molecular effector...