Heparin is widely used as an anticoagulant agent in clinical medication. Recent studies have reported that heparin could have anticancer effects due to its interaction with angiogenesis-related molecules, meaning that it could reduce the formation of new blood vessels and tumorigenesis in the body. ...
However, some factors are briefly considered as selection of MRI sequences and data analysis methods determine not only the range of parameters available, but also their precise meaning. Analysis: descriptive or physiological? Several analysis methods can be applied to DCE-MRI data. Features of the...
has been shown that they have a functional significance in disease, meaning that manipulation of splice isoform levels is able to rescue phenotypes. For example, the “b” isoforms are low in cancer and diabetic nephropathy; however, overexpression or administration of recombinant VEGF-A165b protein...
Thus, the involvement of an additional mechanism could be possible, meaning that tasquinimod may act in LNCaP tumors both by inducing TSP1 production and TAM (M1) recruitment and at the same time inhibit the accumulation of MDSCs and prevent M2 macrophage action via direct interference with the...
The terms “virus,”“viral particle,”“vector particle,”“viral vector particle,” and “virion” are used interchangeably and are to be understood broadly as meaning infectious viral particles that are formed when, e.g., a viral vector of the invention is transduced into an appropriate cell...
It is therefore desired that the examples be considered in all respects as illustrative and not restrictive, reference being made to the appended claims, rather than to the foregoing examples, and all changes which come within the meaning and range of equivalency of the claims are therefore ...
Spacer arm saturation of the film surface was achieved for 25 mol% yield meaning that one spacer arm on four carboxylic acids were covalently bound. Peptide immobilization resulted in binding 10 times less leading to a final 3 mol% yield. Binding densities are governed by their individual space...
However, the meaning of these observations is still in question. The results of Phase III clinical trials that are ongoing will certainly provide more definitive answers with regard to evasive resistance in glioblastoma treated with anti-angiogenic drugs....
Are described glycosaminoglycan derivatives desulfated part, heparin, compounds of formula (I) group R where U, and R have the meaning as described herein) is very particularly. Heparanase and antiangiogenic the glycosaminoglycan derivatives - to have inhibitory activity, no anticoagulant activity.ベニ...
The compounds of formula (I), wherein R, R ', R ", A and D have the meaning as described herein, are useful as therapeutic drugs to alter angiogenesis and anti-tumor characterized by pathological conditions.L·默里尼S·达尔拉维勒S·潘科...