This chapter discusses the development and clinical studies of antianginal drugs. Glyceryl trinitrate and the other short-acting nitrates, commonly used sublingually to terminate the acute attack, are the only drugs of unquestioned value in angina. The chapter summarizes evidence for a beneficial ...
Anti-arrhythmic drugs are classified on the basis of their effects on the rate of depolarization, action potential duration, inhibition of the slow current, beta-adrenergic blockade, etc. Several newer anti-arrhythmic agents are also discussed in the chapter. The major determinants of cardiac ...
Joshi, Gajanan S.; Burnett, James C.; Abraham, Donald J. (2003). "Cardiac Drugs: Antianginal, Vasodilators, Antiarrhythmic". In Abraham, Donald J. Burger's medicinal chemistry and drug discovery. Volume 3: Cardiovascular Agents and Endocrines (6th ed.). Hoboken, N.J.: Wiley....
Chronic angina represents a condition that impairs quality of life and is associated with decreased life expectancy in the industrialized countries. Current therapies that reduce angina frequency include old drugs such as nitrates, 尾 -blockers and calcium antagonists. Several newinvestigational drugs are...
Virginia Commonwealth University Institute for Structural Biology and Drug Discovery School of Pharmacy and Department of Medicinal Chemistry Richmond Virginia USAAmerican Cancer SocietyJoshi, Gajanan S.; Burnett, James C.; Abraham, Donald J. (2003). "Cardiac Drugs: Antianginal, Vasodilators, ...
Antianginal drugs aims at the alleviation, abolition, or prevention of the symptom of angina pectoris, without adversely affecting cardiac performance. Most drugs base their claim for antianginal efficacy on the properties that arelikely to improve the basic coronary insufficiency. No compound is ...