Anti-human TLR7 mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TLR7 amino acids 451-500 purified from E. coli. 来源宿主 小鼠 反应性 人 保存建议 4℃大约保存1个月, 为长期保存, 推荐保存于-20℃。 请避免反复...
A surrogate anti-TLR7 mAb improved survival and reduced autoantibody production in murine lupus model[2]. DS-7011a was generally safe and well tolerated and showed optimal pharmacokinetic (PK) and pharmacodynamic (PD) characteristics in a first-in-human (FIH), single ascending intravenous (IV) ...
In NHP, a single IV infusion of BDB101 showed no significant differences in PK parameters between BDB101 and the total antiPDL1 mAb. BDB101 demonstrated remarkable in vitro stability in human plasma for up to 21 days. In NHP, BDB101 was also very stable with minimal release of free TLR7...