Antibody that immunologically binds to TGF- for use in a procedure to increase bone mass and / or volume in a subject or for use in a procedure to increase bone growth in a subject, wherein said antibody is 1D11 (ATCC Deposit Designation No. HB 9849) or a humanized version of 1D11...
by 1D11 may induce the host immune response which could be helpful for recovery of host anti-tumor immune response inhibited by TGF-尾.The inhibition of TGF-尾 then results in the suppression of prostate cancer growth. This study may lead to the development of effective antitumor therapeutic ...
Mice were injected with 1 mg/mouse (approximately 50 mg/kg) of anti-TGF-beta (1D11) three times per week achieving circulating blood levels of 1-2 mg/ml. Many parameters of immune status were assessed, including natural killer (NK) cell activity, lymphocyte proliferative responses, ...