Anti-S1P Antibody Treatment Produces Near-Complete Mitigation Of Choroidal Neovascularization In AMD ModelExperimental Eye Research
Pharmaceutical compositions comprising an anti-S1 P antibody for ocular administration are also provided. The compositions and methods are particularly useful for treating subjects having age-related macular degeneration, particularly exudative or wet age-related macular degeneration....
Methods for administering combinations of compositions comprising anti-S1P antibodies or antibody fragments and modulators of sphingolipid metabolic pathway enzymes are described. Such methods allow aberrant or undesirable levels of S1P to be reduced in patients known or suspected to have a disease or ...
These methods may be performed in silico and may be intended to enhance binding affinity of an antibody to its original target lipid, and/or to alter binding specificity. Novel antibody variants produced by these methods are also provided, as are methods of making and using them....
Methods for administering combinations of compositions comprising anti-S1P antibodies or antibody fragments and modulators of sphingolipid metabolic pathway enzymes are described. Such methods allow aberrant or undesirable levels of S1P to be reduced in patients known or suspected to have a disease or ...
Methods for administering combinations of compositions comprising anti-S1P antibodies or antibody fragments and modulators of sphingolipid metabolic pathway enzymes are described. Such methods allow aberrant or undesirable levels of S1P to be reduced in patients known or suspected to have a disease or ...
International Journal of Molecular Sciences Article Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells Olivier Blanchard 1, Bisera Stepanovska 1, Manuel Starck 1, Martin Erhardt ...
Rho GTPasessphingosine‐1‐phosphatevasculitisSphingosine‐1‐phosphate (S1P) is a crucial regulator in vascular inflammation. Our recent study found that under pathophysiological concentration in active anti‐neutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV), S1P participated in MPO‐ANCA...
By combination of immunosuppressive agents and S1P receptor agonists / modulators include, but are not limited to anti-lymphocyte antibody inductionS1P receptor modulators during treatment of transplant recipients, immunosuppressive agents and one or more immunosuppressive treatment that combines anti-lymphocyte...
Our previous study revealed that the circulating S1P levels and renal expression of S1PRs correlated with disease activity and renal damage in patients with antineutrophil cytoplasmic antibody (ANCA)???associated vasculitis (AAV). This study investigated the role of S1P and its receptors in ...