Anti-PF4/heparin antibodies are associated with arteriovenous fistula thrombosis in non-dia- betic hemodialysis patients. Clin Exp Nephrol. 2012;16:300-5.Yueh-Feng Tsai,Chien-An Chen,Chieh Kuo,Kao-Chang Lin. Anti-PF4/heparin antibodies are associated with arteriovenous fistula thrombosis in ...
Greinacher A,Juhl D,Strobel U, et al.Heparin-induced thrombocytopenia: a prospective study on the incidence, plateletactivating capacity and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA classes.Journal of Thrombosis and Haemostasis. 2007...
PF4/heparin antibodies were measured using 2 immunoassays. We assessed the probability of HIT by using Warkentin's 4T's scoring system for antibody positive patients and compared routinely performed coagulation test results between patients with and without antibodies to evaluate the ability of these ...
Incidence and clinical relevance of anti-PF4/heparin antibodies before cardiac surgery In some patients, anti-PF4/H antibodies are already detectable before cardiac surgery. Whether preoperative presence of antibodies confers adverse prognosis and which particular antibody classes (IgG, IgA, IgM) might ...
Summary A total of 70 serum samples from heparin-induced thrombocytopenia (HIT II) patients, non-HIT patients and healthy subjects, respectively, were studied for the presence of antiheparin/PF4 antibodies. Two enzyme-linked immunosorbent assay (ELISA) assays were compared with the particle gel...
STAT3 can bind to the promoter of Cx3cl1 gene, we used Moc1 cells and performed chromatin Immunoprecipitation quantitative real-time PCR (ChIP-qPCR) assay using antibodies against STAT3 or IgG (control). We observed enriched occupancy of STAT3 at the promoter regions of CX3CL1 gene compared ...
One peculiar feature of HIT is the transient character of the antibodies. After cessation of exposure to heparins, the antibodies tend to disappear after 40-100 days. If re-immunization occurs, it generally takes at least 4 days to redevelop antibodies (if they are formed at all). We ...
vascularized in order to grow, and that diffusible molecules regulate this process (see, e.g., Auguste et al. 2005 Crit. Rev Oncol Hematol. 54:53-61). Anti-angiogenic molecules include antibodies such as avastatin, small chemical molecules, and endogenous factors among which Platelet Factor 4...
In this study, we evaluate the activity of anti-CD276 antibodies in a chemically-induced murine model of head and neck squamous cell carcinoma. Using models of induced and orthotopic carcinogenesis, we identify ITGB6 as a key gene mediating differential responses to anti-CD276 treatment. Through...
In summary, there is an increased prevalence of anti-PF4/heparin antibodies in patients hospitalized with bacterial but not fungal sepsis. These results indicate that bacterial infection has a role to play in preimmunization leading to anti-PF4/heparin antibody generation....