Monoclonal anti-MMAE antibody, is produced from a hybridoma which was obtained from a mouse immunized with MMAE. 缓冲液 1×PBS, pH7.4. 克隆类型 Monoclonal Antibody 亚型 IgG1 宿主 Mouse 消光系数 1.4 浓度 1 mg/mL 纯度 >94% as determined by reduced SDS-PAGE ...
第二代Payload主要是微管蛋白抑制剂,微管蛋白抑制剂能够干扰有丝分裂,肿瘤细胞分裂速度比大多数正常细胞更快,也使得微管蛋白抑制剂药物对癌细胞杀伤更为有效。微管蛋白抑制剂可以分为两种,一种可促进微管蛋白聚合,使微管生长不受调控,如海兔毒素类衍生物MMAE、MMAF;获批的14款ADC药物中,Payload为海兔毒素类的ADC药物有...
Creative Diagnostics has developed anti-MMAE antibodies and paired conjugates that are suitable for ADC ELISA assay development. It can be used in the quantitative determination of ADC level in test sample, thereby greatly saving the time and costs...
Mouse Anti-MMAE /F mAb (C12A1) Rabbit Anti-DM1/4 pAb Mouse Anti-DM1/4 mAb (F1D5) Mouse Anti-DM1/4 mAb (G2F3) Rabbit Anti-Calicheamicin pAb Mouse Anti-Calicheamicin mAb (B1G9) Mouse Anti-Calicheamicin mAb (C1F12) Rabbit Anti-Duocarmycin pAb Mouse Anti-Duocarmycin mAb (E11A1) ...
嘉兴行健生物科技有限公司在临床医学诊断领域已形成完善的研发、生产和销售的产业化体系。行健生物着眼于研发高端新型临床体外诊断试剂盒,产品涉及不同的人体系统与疾病,包括肿瘤,心血管疾病,内分泌和代谢性疾病,消化道疾病等,行健生物目前已有多个产品注册证在市场上
上海玉博生物科技有限公司做为Creative Diagnostics代理商之产品cabt-b8992-Anti-MMAE monoclonal antibody, clone 3F3 (CABT-B8992)的产品销售公司,专业经营原装进口抗体(单克隆、多克隆)、重组蛋白、检测试剂盒、标准品、细胞因子、胎牛血清、细胞培养类等生物试剂以及耗材。
嘉兴行健生物科技有限公司在临床医学诊断领域已形成完善的研发、生产和销售的产业化体系。行健生物着眼于研发高端新型临床体外诊断试剂盒,产品涉及不同的人体系统与疾病,包括肿瘤,心血管疾病,内分泌和代谢性疾病,消化道疾病等,行健生物目前已有多个产品注册证在市场上
The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur ...
摘要: Human epidermal growth factor receptor-2 (HER2) is a validated therapeutic target for breast cancer and trastuzumab (Herceptin), a humanized anti-HER2 antibody, has significant anti-cancer effects...关键词:HER2 Antibody–drug conjugates Antibody therapy Tumor models MMAE ...
MMAE 是一种有效的有丝分裂抑制剂,通过抑制微管蛋白聚合[1]。 参考文献: [1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.