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In addition, the LSD1/wild-type p53/miR-34a signaling axis was also involved in the regulation of CD47/PD-L1 expression by targeting the 3′ untranslated regions (3′UTRs) of CD47 / PD-L1 . Further, the results showed that an LSD1 inhibitor (ORY-1001) combined with anti-CD47/PD-L1...
张晓晗在《刺青》里说的: 你们年轻人就是这样分分合合藕断丝连爱的时候不真心忘的时候不真诚在一起的时候明明有机会去做很多事为什么要分开了オ去兑现诺言太晚了,时间不对一切都没有意义。 开始一段感情...
Cusan M, Cai SF, Mohammad HP, Krivtsov A, Chramiec A, Loizou E, et al. LSD1 inhibition exerts its anti-leukemic effect by recommissioning PU.1- and C/EBPalpha-dependent enhancers in AML. Blood (2018) 131(15):1730-42. doi:10.1182/blood-2017-09-807024...
Anti-migrationThe overexpression of lysine specific demethylase 1 (LSD1) has been reported in various human tumors. There is increasing interest in targeting LSD1 with small molecules for cancer treatment. A released structure of an LSD1 kinase domain in complex with FAD was used to set up a ...
We previously identified an irreversible LSD1 inhibitor T-3775440, which exerts antileukemic activities in a subset of acute myeloid leukemia (AML) cell lines by inducing cell transdifferentiation. The NEDD8-activating enzyme inhibitor pevonedistat (MLN4924, TAK-924) is an investigational drug with ...